HO-PEG-CH2CH2COOH

Alpha-(hydroxy)-omega-(carboxyethyl) poly(ethylene glycol) (HO-PEG-CH2CH2COOH) is a heterobifunctional precision PEG derivative with a defined chain length. The two ends bear hydroxyl and carboxyethyl groups, respectively. Discrete chain lengths with different degrees of polymerization are available. The terminal hydroxyl group can be further modified by esterification, etherification, or other functional-group transformations. The carboxyethyl group can be activated to couple with amine-containing components. Its two methylene groups provide a local spacer distinct from a carboxymethyl linker. The two end groups can be coupled sequentially using compatible reactions and appropriate protection strategies, enabling surface immobilization, functional-molecule bridging, and directional spacer synthesis.

Customization available.