Mal-PEG-GFLG-COOH

Maleimide-functionalized discrete poly(ethylene glycol)-glycyl-phenylalanyl-leucyl-glycine-carboxylic acid (MAL-PEG-GFLG-COOH) is an ADC linker intermediate containing a defined-length PEG spacer. It contains a maleimide reactive terminus and a glycine–phenylalanine–leucine–glycine tetrapeptide. Discrete chain lengths with different degrees of polymerization are available. The maleimide can add to cysteine thiols or other thiolated modules, providing a handle for conjugation at thiol sites. The glycine–phenylalanine–leucine–glycine tetrapeptide provides a sequence variable for studies of protease-cleavable linkers. The terminal carboxyl group can be activated for coupling with amine-containing modules.

Customization available.