Click Chemistry Reagents

H2N-PEG-N3

Azido-PEG4-Amine (H2N-PEG-N3) is a heterobifunctional precision PEG derivative with a defined chain length. The two ends bear azide and primary amine groups, respectively. Discrete chain lengths with different degrees of polymerization are available. The azide supports conjugation through azide–alkyne click chemistry. The terminal amine can be further modified through amidation or other functional-group transformations, enabling bioconjugation, drug modification, and synthesis of functional PEG derivatives and precision molecular linkers. Applications: Click chemistry; Bioconjugation; Drug modification; Precision PEG derivatization; Bifunctional molecular linker synthesis. Customization available.

N3-PEG-CH2CH2COONHS Ester

Alpha-(azido)-omega-(N-hydroxysuccinimide ester) poly(ethylene glycol) (N3-PEG-NHS) is a heterobifunctional precision PEG derivative with a defined chain length. The two ends bear azide and N-hydroxysuccinimide ester groups, respectively. Discrete chain lengths with different degrees of polymerization are available. The azide can undergo copper-catalyzed click reactions with terminal alkynes or copper-free click conjugation with strained alkynes such as DBCO and BCN. The NHS ester can form amide bonds with primary amines, enabling conjugation to amine-containing small molecules, peptides, proteins, or material surfaces. The two end groups can be coupled sequentially using compatible reactions and appropriate protection strategies, enabling surface immobilization, functional-molecule bridging, and directional spacer synthesis. Applications: Azide click chemistry; Bioorthogonal conjugation; Bifunctional molecular linker synthesis; Amine modification in proteins and peptides; Amine-functionalized surface conjugation; Activated-ester linker synthesis. Customization available.

Alkyne-PEG-NH2

Alpha-(terminal alkyne)-omega-(amino) poly(ethylene glycol) (Alkyne-PEG-NH2) is a heterobifunctional precision PEG derivative with a defined chain length. The two ends bear terminal alkyne and primary amine groups, respectively. Discrete chain lengths with different degrees of polymerization are available. The terminal alkyne can undergo suitable copper-catalyzed cycloaddition with azides, linking the PEG spacer to target molecular modules. The primary amine can react with activated carboxyl groups or NHS esters to form amide bonds and introduce carboxyl-containing functional moieties. The two end groups can be coupled sequentially using compatible reactions and appropriate protection strategies, enabling surface immobilization, functional-molecule bridging, and directional spacer synthesis. Applications: Copper-catalyzed azide–alkyne click chemistry; Probe and ligand assembly; Alkyne-linker synthesis; Amide-based bioconjugation; Peptide and functional small-molecule conjugation; Amino-PEG derivatization. Customization available.

DBCO-PEG-CH2CH2COONHS Ester

Alpha-(dibenzocyclooctyne)-omega-(N-hydroxysuccinimide ester) poly(ethylene glycol) (DBCO-PEG-NHS) is a heterobifunctional precision PEG derivative with a defined chain length. The two ends bear dibenzocyclooctyne (DBCO) and N-hydroxysuccinimide ester groups, respectively. Discrete chain lengths with different degrees of polymerization are available. The strained DBCO alkyne can undergo copper-free click reactions with azides, enabling attachment to molecules or materials with preinstalled azide sites. The NHS ester can form amide bonds with primary amines, enabling conjugation to amine-containing small molecules, peptides, proteins, or material surfaces. The two end groups can be coupled sequentially using compatible reactions and appropriate protection strategies, enabling surface immobilization, functional-molecule bridging, and directional spacer synthesis. Applications: Copper-free click chemistry; Azide-bearing biomolecule labeling; Bioorthogonal linkers; Amine modification in proteins and peptides; Amine-functionalized surface conjugation; Activated-ester linker synthesis. Customization available.

BCN-PEG-NH2

Alpha-(bicyclononyne)-omega-(amino) poly(ethylene glycol) (BCN-PEG-NH2) is a heterobifunctional precision PEG derivative with a defined chain length. The two ends bear bicyclononyne (BCN) and primary amine groups, respectively. Discrete chain lengths with different degrees of polymerization are available. BCN is a strained alkyne that can undergo copper-free cycloaddition with azides, allowing comparisons of different strained-alkyne conjugation termini. The primary amine can react with activated carboxyl groups or NHS esters to form amide bonds and introduce carboxyl-containing functional moieties. The two end groups can be coupled sequentially using compatible reactions and appropriate protection strategies, enabling surface immobilization, functional-molecule bridging, and directional spacer synthesis. Applications: Strain-promoted click conjugation; Azide-probe conjugation; Strained-alkyne end-group structure studies; Amide-based bioconjugation; Peptide and functional small-molecule conjugation; Amino-PEG derivatization. Customization available.

TCO-PEG-CH2CH2COONHS Ester

Alpha-(trans-cyclooctene)-omega-(N-hydroxysuccinimide ester) poly(ethylene glycol) (TCO-PEG-NHS) is a heterobifunctional precision PEG derivative with a defined chain length. The two ends bear trans-cyclooctene (TCO) and N-hydroxysuccinimide ester groups, respectively. Discrete chain lengths with different degrees of polymerization are available. Trans-cyclooctene can pair with tetrazines in inverse-electron-demand Diels–Alder reactions for assembly of bioorthogonal modules. The NHS ester can form amide bonds with primary amines, enabling conjugation to amine-containing small molecules, peptides, proteins, or material surfaces. The two end groups can be coupled sequentially using compatible reactions and appropriate protection strategies, enabling surface immobilization, functional-molecule bridging, and directional spacer synthesis. Applications: Tetrazine-paired bioorthogonal ligation; Rapid probe assembly studies; TCO linker synthesis; Amine modification in proteins and peptides; Amine-functionalized surface conjugation; Activated-ester linker synthesis. Customization available.

N3-PEG-OH

Alpha-(azido)-omega-(hydroxy) poly(ethylene glycol) (N3-PEG-OH) is a heterobifunctional precision PEG derivative with a defined chain length. The two ends bear azide and hydroxyl groups, respectively. Discrete chain lengths with different degrees of polymerization are available. The azide can undergo copper-catalyzed click reactions with terminal alkynes or copper-free click conjugation with strained alkynes such as DBCO and BCN. The terminal hydroxyl group can be further modified by esterification, etherification, or other functional-group transformations. The two end groups can be coupled sequentially using compatible reactions and appropriate protection strategies, enabling surface immobilization, functional-molecule bridging, and directional spacer synthesis. Applications: Azide click chemistry; Bioorthogonal conjugation; Bifunctional molecular linker synthesis; Precision PEG derivatization; Bioconjugation linker synthesis; Drug modification and functional-molecule conjugation. Customization available.

N3-PEG-Mal

Alpha-(azido)-omega-(maleimide) poly(ethylene glycol) (N3-PEG-MAL) is a heterobifunctional precision PEG derivative with a defined chain length. The two ends bear azide and maleimide groups, respectively. Discrete chain lengths with different degrees of polymerization are available. The azide can undergo copper-catalyzed click reactions with terminal alkynes or copper-free click conjugation with strained alkynes such as DBCO and BCN. The maleimide can add to cysteine thiols or other thiolated modules, providing a handle for conjugation at thiol sites. The two end groups can be coupled sequentially using compatible reactions and appropriate protection strategies, enabling surface immobilization, functional-molecule bridging, and directional spacer synthesis. Applications: Azide click chemistry; Bioorthogonal conjugation; Bifunctional molecular linker synthesis; Cysteine-site modification; Thiol-selective bioconjugation; Protein–functional material conjugation. Customization available.

Alkyne-PEG-OH

Alpha-(terminal alkyne)-omega-(hydroxy) poly(ethylene glycol) (Alkyne-PEG-OH) is a heterobifunctional precision PEG derivative with a defined chain length. The two ends bear terminal alkyne and hydroxyl groups, respectively. Discrete chain lengths with different degrees of polymerization are available. The terminal alkyne can undergo suitable copper-catalyzed cycloaddition with azides, linking the PEG spacer to target molecular modules. The terminal hydroxyl group can be further modified by esterification, etherification, or other functional-group transformations. The two end groups can be coupled sequentially using compatible reactions and appropriate protection strategies, enabling surface immobilization, functional-molecule bridging, and directional spacer synthesis. Applications: Copper-catalyzed azide–alkyne click chemistry; Probe and ligand assembly; Alkyne-linker synthesis; Precision PEG derivatization; Bioconjugation linker synthesis; Drug modification and functional-molecule conjugation. Customization available.

Alkyne-PEG-CH2CH2COONHS Ester

Alpha-(terminal alkyne)-omega-(N-hydroxysuccinimide ester) poly(ethylene glycol) (Alkyne-PEG-NHS) is a heterobifunctional precision PEG derivative with a defined chain length. The two ends bear terminal alkyne and N-hydroxysuccinimide ester groups, respectively. Discrete chain lengths with different degrees of polymerization are available. The terminal alkyne can undergo suitable copper-catalyzed cycloaddition with azides, linking the PEG spacer to target molecular modules. The NHS ester can form amide bonds with primary amines, enabling conjugation to amine-containing small molecules, peptides, proteins, or material surfaces. The two end groups can be coupled sequentially using compatible reactions and appropriate protection strategies, enabling surface immobilization, functional-molecule bridging, and directional spacer synthesis. Applications: Copper-catalyzed azide–alkyne click chemistry; Probe and ligand assembly; Alkyne-linker synthesis; Amine modification in proteins and peptides; Amine-functionalized surface conjugation; Activated-ester linker synthesis. Customization available.

Alkyne-PEG-Mal

Alpha-(terminal alkyne)-omega-(maleimide) poly(ethylene glycol) (Alkyne-PEG-MAL) is a heterobifunctional precision PEG derivative with a defined chain length. The two ends bear terminal alkyne and maleimide groups, respectively. Discrete chain lengths with different degrees of polymerization are available. The terminal alkyne can undergo suitable copper-catalyzed cycloaddition with azides, linking the PEG spacer to target molecular modules. The maleimide can add to cysteine thiols or other thiolated modules, providing a handle for conjugation at thiol sites. The two end groups can be coupled sequentially using compatible reactions and appropriate protection strategies, enabling surface immobilization, functional-molecule bridging, and directional spacer synthesis. Applications: Copper-catalyzed azide–alkyne click chemistry; Probe and ligand assembly; Alkyne-linker synthesis; Cysteine-site modification; Thiol-selective bioconjugation; Protein–functional material conjugation. Customization available.

DBCO-PEG-OH

Alpha-(dibenzocyclooctyne)-omega-(hydroxy) poly(ethylene glycol) (DBCO-PEG-OH) is a heterobifunctional precision PEG derivative with a defined chain length. The two ends bear dibenzocyclooctyne (DBCO) and hydroxyl groups, respectively. Discrete chain lengths with different degrees of polymerization are available. The strained DBCO alkyne can undergo copper-free click reactions with azides, enabling attachment to molecules or materials with preinstalled azide sites. The terminal hydroxyl group can be further modified by esterification, etherification, or other functional-group transformations. The two end groups can be coupled sequentially using compatible reactions and appropriate protection strategies, enabling surface immobilization, functional-molecule bridging, and directional spacer synthesis. Applications: Copper-free click chemistry; Azide-bearing biomolecule labeling; Bioorthogonal linkers; Precision PEG derivatization; Bioconjugation linker synthesis; Drug modification and functional-molecule conjugation. Customization available.

DBCO-PEG-NH2

Alpha-(dibenzocyclooctyne)-omega-(amino) poly(ethylene glycol) (DBCO-PEG-NH2) is a heterobifunctional precision PEG derivative with a defined chain length. The two ends bear dibenzocyclooctyne (DBCO) and primary amine groups, respectively. Discrete chain lengths with different degrees of polymerization are available. The strained DBCO alkyne can undergo copper-free click reactions with azides, enabling attachment to molecules or materials with preinstalled azide sites. The primary amine can react with activated carboxyl groups or NHS esters to form amide bonds and introduce carboxyl-containing functional moieties. The two end groups can be coupled sequentially using compatible reactions and appropriate protection strategies, enabling surface immobilization, functional-molecule bridging, and directional spacer synthesis. Applications: Copper-free click chemistry; Azide-bearing biomolecule labeling; Bioorthogonal linkers; Amide-based bioconjugation; Peptide and functional small-molecule conjugation; Amino-PEG derivatization. Customization available.

DBCO-PEG-Mal

Alpha-(dibenzocyclooctyne)-omega-(maleimide) poly(ethylene glycol) (DBCO-PEG-MAL) is a heterobifunctional precision PEG derivative with a defined chain length. The two ends bear dibenzocyclooctyne (DBCO) and maleimide groups, respectively. Discrete chain lengths with different degrees of polymerization are available. The strained DBCO alkyne can undergo copper-free click reactions with azides, enabling attachment to molecules or materials with preinstalled azide sites. The maleimide can add to cysteine thiols or other thiolated modules, providing a handle for conjugation at thiol sites. The two end groups can be coupled sequentially using compatible reactions and appropriate protection strategies, enabling surface immobilization, functional-molecule bridging, and directional spacer synthesis. Applications: Copper-free click chemistry; Azide-bearing biomolecule labeling; Bioorthogonal linkers; Cysteine-site modification; Thiol-selective bioconjugation; Protein–functional material conjugation. Customization available.

BCN-PEG-OH

Alpha-(bicyclononyne)-omega-(hydroxy) poly(ethylene glycol) (BCN-PEG-OH) is a heterobifunctional precision PEG derivative with a defined chain length. The two ends bear bicyclononyne (BCN) and hydroxyl groups, respectively. Discrete chain lengths with different degrees of polymerization are available. BCN is a strained alkyne that can undergo copper-free cycloaddition with azides, allowing comparisons of different strained-alkyne conjugation termini. The terminal hydroxyl group can be further modified by esterification, etherification, or other functional-group transformations. The two end groups can be coupled sequentially using compatible reactions and appropriate protection strategies, enabling surface immobilization, functional-molecule bridging, and directional spacer synthesis. Applications: Strain-promoted click conjugation; Azide-probe conjugation; Strained-alkyne end-group structure studies; Precision PEG derivatization; Bioconjugation linker synthesis; Drug modification and functional-molecule conjugation. Customization available.

BCN-PEG-CH2CH2COONHS Ester

Alpha-(bicyclononyne)-omega-(N-hydroxysuccinimide ester) poly(ethylene glycol) (BCN-PEG-NHS) is a heterobifunctional precision PEG derivative with a defined chain length. The two ends bear bicyclononyne (BCN) and N-hydroxysuccinimide ester groups, respectively. Discrete chain lengths with different degrees of polymerization are available. BCN is a strained alkyne that can undergo copper-free cycloaddition with azides, allowing comparisons of different strained-alkyne conjugation termini. The NHS ester can form amide bonds with primary amines, enabling conjugation to amine-containing small molecules, peptides, proteins, or material surfaces. The two end groups can be coupled sequentially using compatible reactions and appropriate protection strategies, enabling surface immobilization, functional-molecule bridging, and directional spacer synthesis. Applications: Strain-promoted click conjugation; Azide-probe conjugation; Strained-alkyne end-group structure studies; Amine modification in proteins and peptides; Amine-functionalized surface conjugation; Activated-ester linker synthesis. Customization available.

BCN-PEG-Mal

Alpha-(bicyclononyne)-omega-(maleimide) poly(ethylene glycol) (BCN-PEG-MAL) is a heterobifunctional precision PEG derivative with a defined chain length. The two ends bear bicyclononyne (BCN) and maleimide groups, respectively. Discrete chain lengths with different degrees of polymerization are available. BCN is a strained alkyne that can undergo copper-free cycloaddition with azides, allowing comparisons of different strained-alkyne conjugation termini. The maleimide can add to cysteine thiols or other thiolated modules, providing a handle for conjugation at thiol sites. The two end groups can be coupled sequentially using compatible reactions and appropriate protection strategies, enabling surface immobilization, functional-molecule bridging, and directional spacer synthesis. Applications: Strain-promoted click conjugation; Azide-probe conjugation; Strained-alkyne end-group structure studies; Cysteine-site modification; Thiol-selective bioconjugation; Protein–functional material conjugation. Customization available.

TCO-PEG-OH

Alpha-(trans-cyclooctene)-omega-(hydroxy) poly(ethylene glycol) (TCO-PEG-OH) is a heterobifunctional precision PEG derivative with a defined chain length. The two ends bear trans-cyclooctene (TCO) and hydroxyl groups, respectively. Discrete chain lengths with different degrees of polymerization are available. Trans-cyclooctene can pair with tetrazines in inverse-electron-demand Diels–Alder reactions for assembly of bioorthogonal modules. The terminal hydroxyl group can be further modified by esterification, etherification, or other functional-group transformations. The two end groups can be coupled sequentially using compatible reactions and appropriate protection strategies, enabling surface immobilization, functional-molecule bridging, and directional spacer synthesis. Applications: Tetrazine-paired bioorthogonal ligation; Rapid probe assembly studies; TCO linker synthesis; Precision PEG derivatization; Bioconjugation linker synthesis; Drug modification and functional-molecule conjugation. Customization available.

TCO-PEG-NH2

Alpha-(trans-cyclooctene)-omega-(amino) poly(ethylene glycol) (TCO-PEG-NH2) is a heterobifunctional precision PEG derivative with a defined chain length. The two ends bear trans-cyclooctene (TCO) and primary amine groups, respectively. Discrete chain lengths with different degrees of polymerization are available. Trans-cyclooctene can pair with tetrazines in inverse-electron-demand Diels–Alder reactions for assembly of bioorthogonal modules. The primary amine can react with activated carboxyl groups or NHS esters to form amide bonds and introduce carboxyl-containing functional moieties. The two end groups can be coupled sequentially using compatible reactions and appropriate protection strategies, enabling surface immobilization, functional-molecule bridging, and directional spacer synthesis. Applications: Tetrazine-paired bioorthogonal ligation; Rapid probe assembly studies; TCO linker synthesis; Amide-based bioconjugation; Peptide and functional small-molecule conjugation; Amino-PEG derivatization. Customization available.

TCO-PEG-Mal

Alpha-(trans-cyclooctene)-omega-(maleimide) poly(ethylene glycol) (TCO-PEG-MAL) is a heterobifunctional precision PEG derivative with a defined chain length. The two ends bear trans-cyclooctene (TCO) and maleimide groups, respectively. Discrete chain lengths with different degrees of polymerization are available. Trans-cyclooctene can pair with tetrazines in inverse-electron-demand Diels–Alder reactions for assembly of bioorthogonal modules. The maleimide can add to cysteine thiols or other thiolated modules, providing a handle for conjugation at thiol sites. The two end groups can be coupled sequentially using compatible reactions and appropriate protection strategies, enabling surface immobilization, functional-molecule bridging, and directional spacer synthesis. Applications: Tetrazine-paired bioorthogonal ligation; Rapid probe assembly studies; TCO linker synthesis; Cysteine-site modification; Thiol-selective bioconjugation; Protein–functional material conjugation. Customization available.

N3-PEG-CH2CH2COOH

Alpha-(azido)-omega-(carboxy) poly(ethylene glycol) (N3-PEG-COOH) is a heterobifunctional precision PEG derivative with a defined chain length. The two ends bear azide and carboxyl groups, respectively. Discrete chain lengths with different degrees of polymerization are available. The azide can undergo copper-catalyzed click reactions with terminal alkynes or copper-free click conjugation with strained alkynes such as DBCO and BCN. The carboxyl group can be activated for amide coupling with primary-amine-containing molecules, retaining a handle for subsequent ligand or carrier attachment. The two end groups can be coupled sequentially using compatible reactions and appropriate protection strategies, enabling surface immobilization, functional-molecule bridging, and directional spacer synthesis. Applications: Azide click chemistry; Bioorthogonal conjugation; Bifunctional molecular linker synthesis; Amine-containing molecule conjugation; Drug and ligand modification; Carboxyl linker synthesis. Customization available.

Alkyne-PEG-CH2CH2COOH

Alpha-(terminal alkyne)-omega-(carboxy) poly(ethylene glycol) (Alkyne-PEG-COOH) is a heterobifunctional precision PEG derivative with a defined chain length. The two ends bear terminal alkyne and carboxyl groups, respectively. Discrete chain lengths with different degrees of polymerization are available. The terminal alkyne can undergo suitable copper-catalyzed cycloaddition with azides, linking the PEG spacer to target molecular modules. The carboxyl group can be activated for amide coupling with primary-amine-containing molecules, retaining a handle for subsequent ligand or carrier attachment. The two end groups can be coupled sequentially using compatible reactions and appropriate protection strategies, enabling surface immobilization, functional-molecule bridging, and directional spacer synthesis. Applications: Copper-catalyzed azide–alkyne click chemistry; Probe and ligand assembly; Alkyne-linker synthesis; Amine-containing molecule conjugation; Drug and ligand modification; Carboxyl linker synthesis. Customization available.

DBCO-PEG-CH2CH2COOH

Alpha-(dibenzocyclooctyne)-omega-(carboxy) poly(ethylene glycol) (DBCO-PEG-COOH) is a heterobifunctional precision PEG derivative with a defined chain length. The two ends bear dibenzocyclooctyne (DBCO) and carboxyl groups, respectively. Discrete chain lengths with different degrees of polymerization are available. The strained DBCO alkyne can undergo copper-free click reactions with azides, enabling attachment to molecules or materials with preinstalled azide sites. The carboxyl group can be activated for amide coupling with primary-amine-containing molecules, retaining a handle for subsequent ligand or carrier attachment. The two end groups can be coupled sequentially using compatible reactions and appropriate protection strategies, enabling surface immobilization, functional-molecule bridging, and directional spacer synthesis. Applications: Copper-free click chemistry; Azide-bearing biomolecule labeling; Bioorthogonal linkers; Amine-containing molecule conjugation; Drug and ligand modification; Carboxyl linker synthesis. Customization available.

BCN-PEG-CH2CH2COOH

Alpha-(bicyclononyne)-omega-(carboxy) poly(ethylene glycol) (BCN-PEG-COOH) is a heterobifunctional precision PEG derivative with a defined chain length. The two ends bear bicyclononyne (BCN) and carboxyl groups, respectively. Discrete chain lengths with different degrees of polymerization are available. BCN is a strained alkyne that can undergo copper-free cycloaddition with azides, allowing comparisons of different strained-alkyne conjugation termini. The carboxyl group can be activated for amide coupling with primary-amine-containing molecules, retaining a handle for subsequent ligand or carrier attachment. The two end groups can be coupled sequentially using compatible reactions and appropriate protection strategies, enabling surface immobilization, functional-molecule bridging, and directional spacer synthesis. Applications: Strain-promoted click conjugation; Azide-probe conjugation; Strained-alkyne end-group structure studies; Amine-containing molecule conjugation; Drug and ligand modification; Carboxyl linker synthesis. Customization available.

TCO-PEG-CH2CH2COOH

Alpha-(trans-cyclooctene)-omega-(carboxy) poly(ethylene glycol) (TCO-PEG-COOH) is a heterobifunctional precision PEG derivative with a defined chain length. The two ends bear trans-cyclooctene (TCO) and carboxyl groups, respectively. Discrete chain lengths with different degrees of polymerization are available. Trans-cyclooctene can pair with tetrazines in inverse-electron-demand Diels–Alder reactions for assembly of bioorthogonal modules. The carboxyl group can be activated for amide coupling with primary-amine-containing molecules, retaining a handle for subsequent ligand or carrier attachment. The two end groups can be coupled sequentially using compatible reactions and appropriate protection strategies, enabling surface immobilization, functional-molecule bridging, and directional spacer synthesis. Applications: Tetrazine-paired bioorthogonal ligation; Rapid probe assembly studies; TCO linker synthesis; Amine-containing molecule conjugation; Drug and ligand modification; Carboxyl linker synthesis. Customization available.

DBCO-(CH2)n-NH2

DBCO-Mal

DBCO-COONHS Ester

DBCO-CONH-S-S-COONHS Ester

DBCO-NHCO-S-S-COONHS Ester

DBCO-NH-(CH2)nCOOH

Mal-(CH2)n-COOH

Mal-(CH2)n-COONHS Ester

HBr·H2N-O-(CH2)n-COOH

BocNH-(CH2)n-NH2

DBCO-Biotin

Biotin-NHS Ester

Biotin-Hydrazide

Biotin-LC

Biotin-LC-NHS Ester

Biotin-LC-LC

Biotin-LC-LC-NHS Ester

Biotin-SLC

Biotin-SLC-NHS Ester

Biotin-LC-Hydrazide

Biotin-ONP

Biotin-CH2CH2NH2

Biotin-NHCH2CH2-S-S-Pyr

Methyltetrazine-Phenylacetic Acid

Methyltetrazine-NHS Ester

Methyltetrazine-Amine