DBCO-PEG-NH2

Alpha-(dibenzocyclooctyne)-omega-(amino) poly(ethylene glycol) (DBCO-PEG-NH2) is a heterobifunctional precision PEG derivative with a defined chain length. The two ends bear dibenzocyclooctyne (DBCO) and primary amine groups, respectively. Discrete chain lengths with different degrees of polymerization are available. The strained DBCO alkyne can undergo copper-free click reactions with azides, enabling attachment to molecules or materials with preinstalled azide sites. The primary amine can react with activated carboxyl groups or NHS esters to form amide bonds and introduce carboxyl-containing functional moieties. The two end groups can be coupled sequentially using compatible reactions and appropriate protection strategies, enabling surface immobilization, functional-molecule bridging, and directional spacer synthesis.

Customization available.