Alkyne-PEG-NH2

Alpha-(terminal alkyne)-omega-(amino) poly(ethylene glycol) (Alkyne-PEG-NH2) is a heterobifunctional precision PEG derivative with a defined chain length. The two ends bear terminal alkyne and primary amine groups, respectively. Discrete chain lengths with different degrees of polymerization are available. The terminal alkyne can undergo suitable copper-catalyzed cycloaddition with azides, linking the PEG spacer to target molecular modules. The primary amine can react with activated carboxyl groups or NHS esters to form amide bonds and introduce carboxyl-containing functional moieties. The two end groups can be coupled sequentially using compatible reactions and appropriate protection strategies, enabling surface immobilization, functional-molecule bridging, and directional spacer synthesis.

Customization available.