Mal-PEG-Val-Ala-PAB-OH

Maleimide-functionalized discrete poly(ethylene glycol)-valyl-alanine-p-aminobenzyl alcohol (MAL-PEG-Val-Ala-PAB-OH) is an ADC linker intermediate containing a defined-length PEG spacer. It contains a maleimide reactive terminus and a valine–alanine dipeptide. Discrete chain lengths with different degrees of polymerization are available. The maleimide can add to cysteine thiols or other thiolated modules, providing a handle for conjugation at thiol sites. The valine–alanine dipeptide provides a sequence variable for studies of protease-cleavable linkers. The PAB spacer links peptide cleavage to the subsequent self-immolation process. The PAB hydroxyl group retains a synthetic handle for subsequent activation and payload derivatization.

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