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PRODUCT CATEGORY

Precision PEG ADC Linkers

ADC linkers containing oligo-PEG combine structurally defined ethylene glycol spacers with antibody-conjugation termini, cleavable peptide sequences, and payload-attachment sites. Products cover maleimide, azide, primary amine, DBCO, BCN, TCO, Boc-protected amine, and alkyne termini, together with Val-Cit, Val-Ala, GGFG, GFLG, Glu-Val-Cit, Ala-Ala-Asn, disulfide, and hydrazide linking units. PEG chain length, peptide sequence, and terminal activation format are independent catalog parameters for comparing hydrophilic spacer length, steric effects, payload attachment, and release mechanisms. PAB benzyl-alcohol entries allow further activation, while PNP carbonate entries provide sites for attaching amine-containing payloads. Tetrapeptide carboxylic acid, disulfide carboxylic acid, and hydrazide entries support subsequent amidation, reduction-responsive linkage, or hydrazone-formation studies. The catalog is organized by specific end group, peptide sequence, PEG degree of polymerization, and pack size. Each degree of polymerization (DP) has its own SKU. Molecular formulas and exact masses are calculated from the complete structure specified for each entry. A linker is not treated as the complete ADC after payload conjugation.

Mal-PEG-Val-Cit-PAB-OH

Maleimide-functionalized discrete poly(ethylene glycol)-valyl-citrulline-p-aminobenzyl alcohol (MAL-PEG-Val-Cit-PAB-OH) is an ADC linker intermediate containing a defined-length PEG spacer. It contains a maleimide reactive terminus and a valine–citrulline dipeptide. Discrete chain lengths with different degrees of polymerization are available. The maleimide can add to cysteine thiols or other thiolated modules, providing a handle for conjugation at thiol sites. The valine–citrulline dipeptide provides a sequence variable for studies of protease-cleavable linkers. The PAB spacer links peptide cleavage to the subsequent self-immolation process. The PAB hydroxyl group retains a synthetic handle for subsequent activation and payload derivatization. Applications: ADC linker and payload-precursor synthesis; Valine–citrulline dipeptide cleavage studies; Modular antibody conjugation; Cysteine-site modification. Customization available.

n = 4–192 · 30 Catalog Nos.View Series →

Mal-PEG-Val-Cit-PAB-PNP

Maleimide-functionalized discrete poly(ethylene glycol)-valyl-citrulline-p-aminobenzyl p-nitrophenyl carbonate (MAL-PEG-Val-Cit-PAB-PNP) is an ADC linker intermediate containing a defined-length PEG spacer. It contains a maleimide reactive terminus and a valine–citrulline dipeptide. Discrete chain lengths with different degrees of polymerization are available. The maleimide can add to cysteine thiols or other thiolated modules, providing a handle for conjugation at thiol sites. The valine–citrulline dipeptide provides a sequence variable for studies of protease-cleavable linkers. The PAB spacer links peptide cleavage to the subsequent self-immolation process. The PNP-activated terminus can be further coupled to suitable amine-containing payloads. Applications: ADC linker and payload-precursor synthesis; Valine–citrulline dipeptide cleavage studies; Modular antibody conjugation; Cysteine-site modification. Customization available.

n = 4–192 · 30 Catalog Nos.View Series →

Mal-PEG-Val-Ala-PAB-OH

Maleimide-functionalized discrete poly(ethylene glycol)-valyl-alanine-p-aminobenzyl alcohol (MAL-PEG-Val-Ala-PAB-OH) is an ADC linker intermediate containing a defined-length PEG spacer. It contains a maleimide reactive terminus and a valine–alanine dipeptide. Discrete chain lengths with different degrees of polymerization are available. The maleimide can add to cysteine thiols or other thiolated modules, providing a handle for conjugation at thiol sites. The valine–alanine dipeptide provides a sequence variable for studies of protease-cleavable linkers. The PAB spacer links peptide cleavage to the subsequent self-immolation process. The PAB hydroxyl group retains a synthetic handle for subsequent activation and payload derivatization. Applications: ADC linker and payload-precursor synthesis; Valine–alanine dipeptide cleavage studies; Modular antibody conjugation; Cysteine-site modification. Customization available.

n = 4–48 · 25 Catalog Nos.View Series →

Mal-PEG-Val-Ala-PAB-PNP

Maleimide-functionalized discrete poly(ethylene glycol)-valyl-alanine-p-aminobenzyl p-nitrophenyl carbonate (MAL-PEG-Val-Ala-PAB-PNP) is an ADC linker intermediate containing a defined-length PEG spacer. It contains a maleimide reactive terminus and a valine–alanine dipeptide. Discrete chain lengths with different degrees of polymerization are available. The maleimide can add to cysteine thiols or other thiolated modules, providing a handle for conjugation at thiol sites. The valine–alanine dipeptide provides a sequence variable for studies of protease-cleavable linkers. The PAB spacer links peptide cleavage to the subsequent self-immolation process. The PNP-activated terminus can be further coupled to suitable amine-containing payloads. Applications: ADC linker and payload-precursor synthesis; Valine–alanine dipeptide cleavage studies; Modular antibody conjugation; Cysteine-site modification. Customization available.

n = 4–48 · 25 Catalog Nos.View Series →

Mal-PEG-GGFG-COOH

Maleimide-functionalized discrete poly(ethylene glycol)-glycyl-glycyl-phenylalanyl-glycine-carboxylic acid (MAL-PEG-GGFG-COOH) is an ADC linker intermediate containing a defined-length PEG spacer. It contains a maleimide reactive terminus and a glycine–glycine–phenylalanine–glycine tetrapeptide. Discrete chain lengths with different degrees of polymerization are available. The maleimide can add to cysteine thiols or other thiolated modules, providing a handle for conjugation at thiol sites. The glycine–glycine–phenylalanine–glycine tetrapeptide provides a sequence variable for studies of protease-cleavable linkers. The terminal carboxyl group can be activated for coupling with amine-containing modules. Applications: ADC linker and payload-precursor synthesis; Glycine–glycine–phenylalanine–glycine tetrapeptide cleavage studies; Modular antibody conjugation; Cysteine-site modification. Customization available.

n = 4–48 · 25 Catalog Nos.View Series →

Mal-PEG-GFLG-COOH

Maleimide-functionalized discrete poly(ethylene glycol)-glycyl-phenylalanyl-leucyl-glycine-carboxylic acid (MAL-PEG-GFLG-COOH) is an ADC linker intermediate containing a defined-length PEG spacer. It contains a maleimide reactive terminus and a glycine–phenylalanine–leucine–glycine tetrapeptide. Discrete chain lengths with different degrees of polymerization are available. The maleimide can add to cysteine thiols or other thiolated modules, providing a handle for conjugation at thiol sites. The glycine–phenylalanine–leucine–glycine tetrapeptide provides a sequence variable for studies of protease-cleavable linkers. The terminal carboxyl group can be activated for coupling with amine-containing modules. Applications: ADC linker and payload-precursor synthesis; Glycine–phenylalanine–leucine–glycine tetrapeptide cleavage studies; Modular antibody conjugation; Cysteine-site modification. Customization available.

n = 4–48 · 25 Catalog Nos.View Series →

Mal-PEG-Glu-Val-Cit-PAB-OH

Maleimide-functionalized discrete poly(ethylene glycol)-glutamyl-valyl-citrulline-p-aminobenzyl alcohol (MAL-PEG-Glu-Val-Cit-PAB-OH) is an ADC linker intermediate containing a defined-length PEG spacer. It contains a maleimide reactive terminus and a glutamic acid–valine–citrulline tripeptide. Discrete chain lengths with different degrees of polymerization are available. The maleimide can add to cysteine thiols or other thiolated modules, providing a handle for conjugation at thiol sites. The glutamic acid–valine–citrulline tripeptide provides a sequence variable for studies of protease-cleavable linkers. The PAB spacer links peptide cleavage to the subsequent self-immolation process. The PAB hydroxyl group retains a synthetic handle for subsequent activation and payload derivatization. Applications: ADC linker and payload-precursor synthesis; Glutamic acid–valine–citrulline tripeptide cleavage studies; Modular antibody conjugation; Cysteine-site modification. Customization available.

n = 4–48 · 25 Catalog Nos.View Series →

Mal-PEG-Ala-Ala-Asn-PAB-OH

Maleimide-functionalized discrete poly(ethylene glycol)-alanyl-alanyl-asparagine-p-aminobenzyl alcohol (MAL-PEG-Ala-Ala-Asn-PAB-OH) is an ADC linker intermediate containing a defined-length PEG spacer. It contains a maleimide reactive terminus and an alanine–alanine–asparagine tripeptide. Discrete chain lengths with different degrees of polymerization are available. The maleimide can add to cysteine thiols or other thiolated modules, providing a handle for conjugation at thiol sites. The alanine–alanine–asparagine tripeptide provides a sequence variable for studies of protease-cleavable linkers. The PAB spacer links peptide cleavage to the subsequent self-immolation process. The PAB hydroxyl group retains a synthetic handle for subsequent activation and payload derivatization. Applications: ADC linker and payload-precursor synthesis; Alanine–alanine–asparagine tripeptide cleavage studies; Modular antibody conjugation; Cysteine-site modification. Customization available.

n = 4–48 · 25 Catalog Nos.View Series →

Mal-PEG-SS-COOH

Maleimide-functionalized discrete poly(ethylene glycol)-disulfide-carboxylic acid (MAL-PEG-SS-COOH) is an ADC linker intermediate containing a defined-length PEG spacer. It contains a maleimide reactive terminus and a disulfide linkage. Discrete chain lengths with different degrees of polymerization are available. The maleimide can add to cysteine thiols or other thiolated modules, providing a handle for conjugation at thiol sites. The disulfide can act as a reduction-responsive linking unit. After activation, the carboxyl group can be used to attach amine-containing payloads or other modules. Applications: Reduction-responsive ADC linkers; Disulfide-containing payload-module assembly; Antibody–carrier conjugation studies; Cysteine-site modification. Customization available.

n = 4–48 · 25 Catalog Nos.View Series →

Mal-PEG-Hydrazide

Maleimide-functionalized discrete poly(ethylene glycol)-hydrazide (MAL-PEG-Hydrazide) is an ADC linker intermediate containing a defined-length PEG spacer. It contains a maleimide reactive terminus and a hydrazide group. Discrete chain lengths with different degrees of polymerization are available. The maleimide can add to cysteine thiols or other thiolated modules, providing a handle for conjugation at thiol sites. The hydrazide at the other end can form hydrazone linkages with aldehydes or ketones, allowing carbonyl capture and reactions at the other terminus to be performed sequentially. Applications: Acid-responsive hydrazone linkers; Carbonyl-containing payload conjugation; ADC module synthesis; Cysteine-site modification. Customization available.

n = 4–48 · 25 Catalog Nos.View Series →

N3-PEG-Val-Cit-PAB-OH

Azido-functionalized discrete poly(ethylene glycol)-valyl-citrulline-p-aminobenzyl alcohol (N3-PEG-Val-Cit-PAB-OH) is an ADC linker intermediate containing a defined-length PEG spacer. It contains an azide reactive terminus and a valine–citrulline dipeptide. Discrete chain lengths with different degrees of polymerization are available. The azide can undergo copper-catalyzed click reactions with terminal alkynes or copper-free click conjugation with strained alkynes such as DBCO and BCN. The valine–citrulline dipeptide provides a sequence variable for studies of protease-cleavable linkers. The PAB spacer links peptide cleavage to the subsequent self-immolation process. The PAB hydroxyl group retains a synthetic handle for subsequent activation and payload derivatization. Applications: ADC linker and payload-precursor synthesis; Valine–citrulline dipeptide cleavage studies; Modular antibody conjugation; Azide click chemistry. Customization available.

n = 4–48 · 25 Catalog Nos.View Series →

N3-PEG-Val-Cit-PAB-PNP

Azido-functionalized discrete poly(ethylene glycol)-valyl-citrulline-p-aminobenzyl p-nitrophenyl carbonate (N3-PEG-Val-Cit-PAB-PNP) is an ADC linker intermediate containing a defined-length PEG spacer. It contains an azide reactive terminus and a valine–citrulline dipeptide. Discrete chain lengths with different degrees of polymerization are available. The azide can undergo copper-catalyzed click reactions with terminal alkynes or copper-free click conjugation with strained alkynes such as DBCO and BCN. The valine–citrulline dipeptide provides a sequence variable for studies of protease-cleavable linkers. The PAB spacer links peptide cleavage to the subsequent self-immolation process. The PNP-activated terminus can be further coupled to suitable amine-containing payloads. Applications: ADC linker and payload-precursor synthesis; Valine–citrulline dipeptide cleavage studies; Modular antibody conjugation; Azide click chemistry. Customization available.

n = 4–48 · 25 Catalog Nos.View Series →

N3-PEG-Val-Ala-PAB-OH

Azido-functionalized discrete poly(ethylene glycol)-valyl-alanine-p-aminobenzyl alcohol (N3-PEG-Val-Ala-PAB-OH) is an ADC linker intermediate containing a defined-length PEG spacer. It contains an azide reactive terminus and a valine–alanine dipeptide. Discrete chain lengths with different degrees of polymerization are available. The azide can undergo copper-catalyzed click reactions with terminal alkynes or copper-free click conjugation with strained alkynes such as DBCO and BCN. The valine–alanine dipeptide provides a sequence variable for studies of protease-cleavable linkers. The PAB spacer links peptide cleavage to the subsequent self-immolation process. The PAB hydroxyl group retains a synthetic handle for subsequent activation and payload derivatization. Applications: ADC linker and payload-precursor synthesis; Valine–alanine dipeptide cleavage studies; Modular antibody conjugation; Azide click chemistry. Customization available.

n = 4–48 · 25 Catalog Nos.View Series →

N3-PEG-Val-Ala-PAB-PNP

Azido-functionalized discrete poly(ethylene glycol)-valyl-alanine-p-aminobenzyl p-nitrophenyl carbonate (N3-PEG-Val-Ala-PAB-PNP) is an ADC linker intermediate containing a defined-length PEG spacer. It contains an azide reactive terminus and a valine–alanine dipeptide. Discrete chain lengths with different degrees of polymerization are available. The azide can undergo copper-catalyzed click reactions with terminal alkynes or copper-free click conjugation with strained alkynes such as DBCO and BCN. The valine–alanine dipeptide provides a sequence variable for studies of protease-cleavable linkers. The PAB spacer links peptide cleavage to the subsequent self-immolation process. The PNP-activated terminus can be further coupled to suitable amine-containing payloads. Applications: ADC linker and payload-precursor synthesis; Valine–alanine dipeptide cleavage studies; Modular antibody conjugation; Azide click chemistry. Customization available.

n = 4–48 · 25 Catalog Nos.View Series →

N3-PEG-GGFG-COOH

Azido-functionalized discrete poly(ethylene glycol)-glycyl-glycyl-phenylalanyl-glycine-carboxylic acid (N3-PEG-GGFG-COOH) is an ADC linker intermediate containing a defined-length PEG spacer. It contains an azide reactive terminus and a glycine–glycine–phenylalanine–glycine tetrapeptide. Discrete chain lengths with different degrees of polymerization are available. The azide can undergo copper-catalyzed click reactions with terminal alkynes or copper-free click conjugation with strained alkynes such as DBCO and BCN. The glycine–glycine–phenylalanine–glycine tetrapeptide provides a sequence variable for studies of protease-cleavable linkers. The terminal carboxyl group can be activated for coupling with amine-containing modules. Applications: ADC linker and payload-precursor synthesis; Glycine–glycine–phenylalanine–glycine tetrapeptide cleavage studies; Modular antibody conjugation; Azide click chemistry. Customization available.

n = 4–48 · 25 Catalog Nos.View Series →

N3-PEG-GFLG-COOH

Azido-functionalized discrete poly(ethylene glycol)-glycyl-phenylalanyl-leucyl-glycine-carboxylic acid (N3-PEG-GFLG-COOH) is an ADC linker intermediate containing a defined-length PEG spacer. It contains an azide reactive terminus and a glycine–phenylalanine–leucine–glycine tetrapeptide. Discrete chain lengths with different degrees of polymerization are available. The azide can undergo copper-catalyzed click reactions with terminal alkynes or copper-free click conjugation with strained alkynes such as DBCO and BCN. The glycine–phenylalanine–leucine–glycine tetrapeptide provides a sequence variable for studies of protease-cleavable linkers. The terminal carboxyl group can be activated for coupling with amine-containing modules. Applications: ADC linker and payload-precursor synthesis; Glycine–phenylalanine–leucine–glycine tetrapeptide cleavage studies; Modular antibody conjugation; Azide click chemistry. Customization available.

n = 4–48 · 25 Catalog Nos.View Series →

N3-PEG-Glu-Val-Cit-PAB-OH

Azido-functionalized discrete poly(ethylene glycol)-glutamyl-valyl-citrulline-p-aminobenzyl alcohol (N3-PEG-Glu-Val-Cit-PAB-OH) is an ADC linker intermediate containing a defined-length PEG spacer. It contains an azide reactive terminus and a glutamic acid–valine–citrulline tripeptide. Discrete chain lengths with different degrees of polymerization are available. The azide can undergo copper-catalyzed click reactions with terminal alkynes or copper-free click conjugation with strained alkynes such as DBCO and BCN. The glutamic acid–valine–citrulline tripeptide provides a sequence variable for studies of protease-cleavable linkers. The PAB spacer links peptide cleavage to the subsequent self-immolation process. The PAB hydroxyl group retains a synthetic handle for subsequent activation and payload derivatization. Applications: ADC linker and payload-precursor synthesis; Glutamic acid–valine–citrulline tripeptide cleavage studies; Modular antibody conjugation; Azide click chemistry. Customization available.

n = 4–48 · 25 Catalog Nos.View Series →

N3-PEG-Ala-Ala-Asn-PAB-OH

Azido-functionalized discrete poly(ethylene glycol)-alanyl-alanyl-asparagine-p-aminobenzyl alcohol (N3-PEG-Ala-Ala-Asn-PAB-OH) is an ADC linker intermediate containing a defined-length PEG spacer. It contains an azide reactive terminus and an alanine–alanine–asparagine tripeptide. Discrete chain lengths with different degrees of polymerization are available. The azide can undergo copper-catalyzed click reactions with terminal alkynes or copper-free click conjugation with strained alkynes such as DBCO and BCN. The alanine–alanine–asparagine tripeptide provides a sequence variable for studies of protease-cleavable linkers. The PAB spacer links peptide cleavage to the subsequent self-immolation process. The PAB hydroxyl group retains a synthetic handle for subsequent activation and payload derivatization. Applications: ADC linker and payload-precursor synthesis; Alanine–alanine–asparagine tripeptide cleavage studies; Modular antibody conjugation; Azide click chemistry. Customization available.

n = 4–48 · 25 Catalog Nos.View Series →

N3-PEG-SS-COOH

Azido-functionalized discrete poly(ethylene glycol)-disulfide-carboxylic acid (N3-PEG-SS-COOH) is an ADC linker intermediate containing a defined-length PEG spacer. It contains an azide reactive terminus and a disulfide linkage. Discrete chain lengths with different degrees of polymerization are available. The azide can undergo copper-catalyzed click reactions with terminal alkynes or copper-free click conjugation with strained alkynes such as DBCO and BCN. The disulfide can act as a reduction-responsive linking unit. After activation, the carboxyl group can be used to attach amine-containing payloads or other modules. Applications: Reduction-responsive ADC linkers; Disulfide-containing payload-module assembly; Antibody–carrier conjugation studies; Azide click chemistry. Customization available.

n = 4–48 · 25 Catalog Nos.View Series →

N3-PEG-Hydrazide

Azido-functionalized discrete poly(ethylene glycol)-hydrazide (N3-PEG-Hydrazide) is an ADC linker intermediate containing a defined-length PEG spacer. It contains an azide reactive terminus and a hydrazide group. Discrete chain lengths with different degrees of polymerization are available. The azide can undergo copper-catalyzed click reactions with terminal alkynes or copper-free click conjugation with strained alkynes such as DBCO and BCN. The hydrazide at the other end can form hydrazone linkages with aldehydes or ketones, allowing carbonyl capture and reactions at the other terminus to be performed sequentially. Applications: Acid-responsive hydrazone linkers; Carbonyl-containing payload conjugation; ADC module synthesis; Azide click chemistry. Customization available.

n = 3–48 · 26 Catalog Nos.View Series →

H2N-PEG-Val-Cit-PAB-OH

Primary amine-functionalized discrete poly(ethylene glycol)-valyl-citrulline-p-aminobenzyl alcohol (H2N-PEG-Val-Cit-PAB-OH) is an ADC linker intermediate containing a defined-length PEG spacer. It contains a primary amine reactive terminus and a valine–citrulline dipeptide. Discrete chain lengths with different degrees of polymerization are available. The primary amine can react with activated carboxyl groups or NHS esters to form amide bonds and introduce carboxyl-containing functional moieties. The valine–citrulline dipeptide provides a sequence variable for studies of protease-cleavable linkers. The PAB spacer links peptide cleavage to the subsequent self-immolation process. The PAB hydroxyl group retains a synthetic handle for subsequent activation and payload derivatization. Applications: ADC linker and payload-precursor synthesis; Valine–citrulline dipeptide cleavage studies; Modular antibody conjugation; Amide-based bioconjugation. Customization available.

n = 4–48 · 25 Catalog Nos.View Series →

H2N-PEG-Val-Cit-PAB-PNP

Primary amine-functionalized discrete poly(ethylene glycol)-valyl-citrulline-p-aminobenzyl p-nitrophenyl carbonate (H2N-PEG-Val-Cit-PAB-PNP) is an ADC linker intermediate containing a defined-length PEG spacer. It contains a primary amine reactive terminus and a valine–citrulline dipeptide. Discrete chain lengths with different degrees of polymerization are available. The primary amine can react with activated carboxyl groups or NHS esters to form amide bonds and introduce carboxyl-containing functional moieties. The valine–citrulline dipeptide provides a sequence variable for studies of protease-cleavable linkers. The PAB spacer links peptide cleavage to the subsequent self-immolation process. The PNP-activated terminus can be further coupled to suitable amine-containing payloads. Applications: ADC linker and payload-precursor synthesis; Valine–citrulline dipeptide cleavage studies; Modular antibody conjugation; Amide-based bioconjugation. Customization available.

n = 4–48 · 25 Catalog Nos.View Series →

H2N-PEG-Val-Ala-PAB-OH

Primary amine-functionalized discrete poly(ethylene glycol)-valyl-alanine-p-aminobenzyl alcohol (H2N-PEG-Val-Ala-PAB-OH) is an ADC linker intermediate containing a defined-length PEG spacer. It contains a primary amine reactive terminus and a valine–alanine dipeptide. Discrete chain lengths with different degrees of polymerization are available. The primary amine can react with activated carboxyl groups or NHS esters to form amide bonds and introduce carboxyl-containing functional moieties. The valine–alanine dipeptide provides a sequence variable for studies of protease-cleavable linkers. The PAB spacer links peptide cleavage to the subsequent self-immolation process. The PAB hydroxyl group retains a synthetic handle for subsequent activation and payload derivatization. Applications: ADC linker and payload-precursor synthesis; Valine–alanine dipeptide cleavage studies; Modular antibody conjugation; Amide-based bioconjugation. Customization available.

n = 4–48 · 25 Catalog Nos.View Series →

H2N-PEG-Val-Ala-PAB-PNP

Primary amine-functionalized discrete poly(ethylene glycol)-valyl-alanine-p-aminobenzyl p-nitrophenyl carbonate (H2N-PEG-Val-Ala-PAB-PNP) is an ADC linker intermediate containing a defined-length PEG spacer. It contains a primary amine reactive terminus and a valine–alanine dipeptide. Discrete chain lengths with different degrees of polymerization are available. The primary amine can react with activated carboxyl groups or NHS esters to form amide bonds and introduce carboxyl-containing functional moieties. The valine–alanine dipeptide provides a sequence variable for studies of protease-cleavable linkers. The PAB spacer links peptide cleavage to the subsequent self-immolation process. The PNP-activated terminus can be further coupled to suitable amine-containing payloads. Applications: ADC linker and payload-precursor synthesis; Valine–alanine dipeptide cleavage studies; Modular antibody conjugation; Amide-based bioconjugation. Customization available.

n = 4–48 · 25 Catalog Nos.View Series →

H2N-PEG-GGFG-COOH

Primary amine-functionalized discrete poly(ethylene glycol)-glycyl-glycyl-phenylalanyl-glycine-carboxylic acid (H2N-PEG-GGFG-COOH) is an ADC linker intermediate containing a defined-length PEG spacer. It contains a primary amine reactive terminus and a glycine–glycine–phenylalanine–glycine tetrapeptide. Discrete chain lengths with different degrees of polymerization are available. The primary amine can react with activated carboxyl groups or NHS esters to form amide bonds and introduce carboxyl-containing functional moieties. The glycine–glycine–phenylalanine–glycine tetrapeptide provides a sequence variable for studies of protease-cleavable linkers. The terminal carboxyl group can be activated for coupling with amine-containing modules. Applications: ADC linker and payload-precursor synthesis; Glycine–glycine–phenylalanine–glycine tetrapeptide cleavage studies; Modular antibody conjugation; Amide-based bioconjugation. Customization available.

n = 4–48 · 25 Catalog Nos.View Series →

H2N-PEG-GFLG-COOH

Primary amine-functionalized discrete poly(ethylene glycol)-glycyl-phenylalanyl-leucyl-glycine-carboxylic acid (H2N-PEG-GFLG-COOH) is an ADC linker intermediate containing a defined-length PEG spacer. It contains a primary amine reactive terminus and a glycine–phenylalanine–leucine–glycine tetrapeptide. Discrete chain lengths with different degrees of polymerization are available. The primary amine can react with activated carboxyl groups or NHS esters to form amide bonds and introduce carboxyl-containing functional moieties. The glycine–phenylalanine–leucine–glycine tetrapeptide provides a sequence variable for studies of protease-cleavable linkers. The terminal carboxyl group can be activated for coupling with amine-containing modules. Applications: ADC linker and payload-precursor synthesis; Glycine–phenylalanine–leucine–glycine tetrapeptide cleavage studies; Modular antibody conjugation; Amide-based bioconjugation. Customization available.

n = 4–48 · 25 Catalog Nos.View Series →

H2N-PEG-Glu-Val-Cit-PAB-OH

Primary amine-functionalized discrete poly(ethylene glycol)-glutamyl-valyl-citrulline-p-aminobenzyl alcohol (H2N-PEG-Glu-Val-Cit-PAB-OH) is an ADC linker intermediate containing a defined-length PEG spacer. It contains a primary amine reactive terminus and a glutamic acid–valine–citrulline tripeptide. Discrete chain lengths with different degrees of polymerization are available. The primary amine can react with activated carboxyl groups or NHS esters to form amide bonds and introduce carboxyl-containing functional moieties. The glutamic acid–valine–citrulline tripeptide provides a sequence variable for studies of protease-cleavable linkers. The PAB spacer links peptide cleavage to the subsequent self-immolation process. The PAB hydroxyl group retains a synthetic handle for subsequent activation and payload derivatization. Applications: ADC linker and payload-precursor synthesis; Glutamic acid–valine–citrulline tripeptide cleavage studies; Modular antibody conjugation; Amide-based bioconjugation. Customization available.

n = 4–48 · 25 Catalog Nos.View Series →

H2N-PEG-Ala-Ala-Asn-PAB-OH

Primary amine-functionalized discrete poly(ethylene glycol)-alanyl-alanyl-asparagine-p-aminobenzyl alcohol (H2N-PEG-Ala-Ala-Asn-PAB-OH) is an ADC linker intermediate containing a defined-length PEG spacer. It contains a primary amine reactive terminus and an alanine–alanine–asparagine tripeptide. Discrete chain lengths with different degrees of polymerization are available. The primary amine can react with activated carboxyl groups or NHS esters to form amide bonds and introduce carboxyl-containing functional moieties. The alanine–alanine–asparagine tripeptide provides a sequence variable for studies of protease-cleavable linkers. The PAB spacer links peptide cleavage to the subsequent self-immolation process. The PAB hydroxyl group retains a synthetic handle for subsequent activation and payload derivatization. Applications: ADC linker and payload-precursor synthesis; Alanine–alanine–asparagine tripeptide cleavage studies; Modular antibody conjugation; Amide-based bioconjugation. Customization available.

n = 4–48 · 25 Catalog Nos.View Series →

H2N-PEG-SS-COOH

Primary amine-functionalized discrete poly(ethylene glycol)-disulfide-carboxylic acid (H2N-PEG-SS-COOH) is an ADC linker intermediate containing a defined-length PEG spacer. It contains a primary amine reactive terminus and a disulfide linkage. Discrete chain lengths with different degrees of polymerization are available. The primary amine can react with activated carboxyl groups or NHS esters to form amide bonds and introduce carboxyl-containing functional moieties. The disulfide can act as a reduction-responsive linking unit. After activation, the carboxyl group can be used to attach amine-containing payloads or other modules. Applications: Reduction-responsive ADC linkers; Disulfide-containing payload-module assembly; Antibody–carrier conjugation studies; Amide-based bioconjugation. Customization available.

n = 4–48 · 25 Catalog Nos.View Series →

H2N-PEG-Hydrazide

Primary amine-functionalized discrete poly(ethylene glycol)-hydrazide (H2N-PEG-Hydrazide) is an ADC linker intermediate containing a defined-length PEG spacer. It contains a primary amine reactive terminus and a hydrazide group. Discrete chain lengths with different degrees of polymerization are available. The primary amine can react with activated carboxyl groups or NHS esters to form amide bonds and introduce carboxyl-containing functional moieties. The hydrazide at the other end can form hydrazone linkages with aldehydes or ketones, allowing carbonyl capture and reactions at the other terminus to be performed sequentially. Applications: Acid-responsive hydrazone linkers; Carbonyl-containing payload conjugation; ADC module synthesis; Amide-based bioconjugation. Customization available.

n = 4–48 · 25 Catalog Nos.View Series →

DBCO-PEG-Val-Cit-PAB-OH

Dibenzocyclooctyne-functionalized discrete poly(ethylene glycol)-valyl-citrulline-p-aminobenzyl alcohol (DBCO-PEG-Val-Cit-PAB-OH) is an ADC linker intermediate containing a defined-length PEG spacer. It contains a dibenzocyclooctyne (DBCO) reactive terminus and a valine–citrulline dipeptide. Discrete chain lengths with different degrees of polymerization are available. The strained DBCO alkyne can undergo copper-free click reactions with azides, enabling attachment to molecules or materials with preinstalled azide sites. The valine–citrulline dipeptide provides a sequence variable for studies of protease-cleavable linkers. The PAB spacer links peptide cleavage to the subsequent self-immolation process. The PAB hydroxyl group retains a synthetic handle for subsequent activation and payload derivatization. Applications: ADC linker and payload-precursor synthesis; Valine–citrulline dipeptide cleavage studies; Modular antibody conjugation; Copper-free click chemistry. Customization available.

n = 4–48 · 25 Catalog Nos.View Series →

DBCO-PEG-Val-Cit-PAB-PNP

Dibenzocyclooctyne-functionalized discrete poly(ethylene glycol)-valyl-citrulline-p-aminobenzyl p-nitrophenyl carbonate (DBCO-PEG-Val-Cit-PAB-PNP) is an ADC linker intermediate containing a defined-length PEG spacer. It contains a dibenzocyclooctyne (DBCO) reactive terminus and a valine–citrulline dipeptide. Discrete chain lengths with different degrees of polymerization are available. The strained DBCO alkyne can undergo copper-free click reactions with azides, enabling attachment to molecules or materials with preinstalled azide sites. The valine–citrulline dipeptide provides a sequence variable for studies of protease-cleavable linkers. The PAB spacer links peptide cleavage to the subsequent self-immolation process. The PNP-activated terminus can be further coupled to suitable amine-containing payloads. Applications: ADC linker and payload-precursor synthesis; Valine–citrulline dipeptide cleavage studies; Modular antibody conjugation; Copper-free click chemistry. Customization available.

n = 4–48 · 25 Catalog Nos.View Series →

DBCO-PEG-Val-Ala-PAB-OH

Dibenzocyclooctyne-functionalized discrete poly(ethylene glycol)-valyl-alanine-p-aminobenzyl alcohol (DBCO-PEG-Val-Ala-PAB-OH) is an ADC linker intermediate containing a defined-length PEG spacer. It contains a dibenzocyclooctyne (DBCO) reactive terminus and a valine–alanine dipeptide. Discrete chain lengths with different degrees of polymerization are available. The strained DBCO alkyne can undergo copper-free click reactions with azides, enabling attachment to molecules or materials with preinstalled azide sites. The valine–alanine dipeptide provides a sequence variable for studies of protease-cleavable linkers. The PAB spacer links peptide cleavage to the subsequent self-immolation process. The PAB hydroxyl group retains a synthetic handle for subsequent activation and payload derivatization. Applications: ADC linker and payload-precursor synthesis; Valine–alanine dipeptide cleavage studies; Modular antibody conjugation; Copper-free click chemistry. Customization available.

n = 4–48 · 25 Catalog Nos.View Series →

DBCO-PEG-Val-Ala-PAB-PNP

Dibenzocyclooctyne-functionalized discrete poly(ethylene glycol)-valyl-alanine-p-aminobenzyl p-nitrophenyl carbonate (DBCO-PEG-Val-Ala-PAB-PNP) is an ADC linker intermediate containing a defined-length PEG spacer. It contains a dibenzocyclooctyne (DBCO) reactive terminus and a valine–alanine dipeptide. Discrete chain lengths with different degrees of polymerization are available. The strained DBCO alkyne can undergo copper-free click reactions with azides, enabling attachment to molecules or materials with preinstalled azide sites. The valine–alanine dipeptide provides a sequence variable for studies of protease-cleavable linkers. The PAB spacer links peptide cleavage to the subsequent self-immolation process. The PNP-activated terminus can be further coupled to suitable amine-containing payloads. Applications: ADC linker and payload-precursor synthesis; Valine–alanine dipeptide cleavage studies; Modular antibody conjugation; Copper-free click chemistry. Customization available.

n = 4–48 · 25 Catalog Nos.View Series →

DBCO-PEG-GGFG-COOH

Dibenzocyclooctyne-functionalized discrete poly(ethylene glycol)-glycyl-glycyl-phenylalanyl-glycine-carboxylic acid (DBCO-PEG-GGFG-COOH) is an ADC linker intermediate containing a defined-length PEG spacer. It contains a dibenzocyclooctyne (DBCO) reactive terminus and a glycine–glycine–phenylalanine–glycine tetrapeptide. Discrete chain lengths with different degrees of polymerization are available. The strained DBCO alkyne can undergo copper-free click reactions with azides, enabling attachment to molecules or materials with preinstalled azide sites. The glycine–glycine–phenylalanine–glycine tetrapeptide provides a sequence variable for studies of protease-cleavable linkers. The terminal carboxyl group can be activated for coupling with amine-containing modules. Applications: ADC linker and payload-precursor synthesis; Glycine–glycine–phenylalanine–glycine tetrapeptide cleavage studies; Modular antibody conjugation; Copper-free click chemistry. Customization available.

n = 4–48 · 25 Catalog Nos.View Series →

DBCO-PEG-GFLG-COOH

Dibenzocyclooctyne-functionalized discrete poly(ethylene glycol)-glycyl-phenylalanyl-leucyl-glycine-carboxylic acid (DBCO-PEG-GFLG-COOH) is an ADC linker intermediate containing a defined-length PEG spacer. It contains a dibenzocyclooctyne (DBCO) reactive terminus and a glycine–phenylalanine–leucine–glycine tetrapeptide. Discrete chain lengths with different degrees of polymerization are available. The strained DBCO alkyne can undergo copper-free click reactions with azides, enabling attachment to molecules or materials with preinstalled azide sites. The glycine–phenylalanine–leucine–glycine tetrapeptide provides a sequence variable for studies of protease-cleavable linkers. The terminal carboxyl group can be activated for coupling with amine-containing modules. Applications: ADC linker and payload-precursor synthesis; Glycine–phenylalanine–leucine–glycine tetrapeptide cleavage studies; Modular antibody conjugation; Copper-free click chemistry. Customization available.

n = 4–48 · 25 Catalog Nos.View Series →

DBCO-PEG-Glu-Val-Cit-PAB-OH

Dibenzocyclooctyne-functionalized discrete poly(ethylene glycol)-glutamyl-valyl-citrulline-p-aminobenzyl alcohol (DBCO-PEG-Glu-Val-Cit-PAB-OH) is an ADC linker intermediate containing a defined-length PEG spacer. It contains a dibenzocyclooctyne (DBCO) reactive terminus and a glutamic acid–valine–citrulline tripeptide. Discrete chain lengths with different degrees of polymerization are available. The strained DBCO alkyne can undergo copper-free click reactions with azides, enabling attachment to molecules or materials with preinstalled azide sites. The glutamic acid–valine–citrulline tripeptide provides a sequence variable for studies of protease-cleavable linkers. The PAB spacer links peptide cleavage to the subsequent self-immolation process. The PAB hydroxyl group retains a synthetic handle for subsequent activation and payload derivatization. Applications: ADC linker and payload-precursor synthesis; Glutamic acid–valine–citrulline tripeptide cleavage studies; Modular antibody conjugation; Copper-free click chemistry. Customization available.

n = 4–48 · 25 Catalog Nos.View Series →

DBCO-PEG-Ala-Ala-Asn-PAB-OH

Dibenzocyclooctyne-functionalized discrete poly(ethylene glycol)-alanyl-alanyl-asparagine-p-aminobenzyl alcohol (DBCO-PEG-Ala-Ala-Asn-PAB-OH) is an ADC linker intermediate containing a defined-length PEG spacer. It contains a dibenzocyclooctyne (DBCO) reactive terminus and an alanine–alanine–asparagine tripeptide. Discrete chain lengths with different degrees of polymerization are available. The strained DBCO alkyne can undergo copper-free click reactions with azides, enabling attachment to molecules or materials with preinstalled azide sites. The alanine–alanine–asparagine tripeptide provides a sequence variable for studies of protease-cleavable linkers. The PAB spacer links peptide cleavage to the subsequent self-immolation process. The PAB hydroxyl group retains a synthetic handle for subsequent activation and payload derivatization. Applications: ADC linker and payload-precursor synthesis; Alanine–alanine–asparagine tripeptide cleavage studies; Modular antibody conjugation; Copper-free click chemistry. Customization available.

n = 4–48 · 25 Catalog Nos.View Series →

DBCO-PEG-SS-COOH

Dibenzocyclooctyne-functionalized discrete poly(ethylene glycol)-disulfide-carboxylic acid (DBCO-PEG-SS-COOH) is an ADC linker intermediate containing a defined-length PEG spacer. It contains a dibenzocyclooctyne (DBCO) reactive terminus and a disulfide linkage. Discrete chain lengths with different degrees of polymerization are available. The strained DBCO alkyne can undergo copper-free click reactions with azides, enabling attachment to molecules or materials with preinstalled azide sites. The disulfide can act as a reduction-responsive linking unit. After activation, the carboxyl group can be used to attach amine-containing payloads or other modules. Applications: Reduction-responsive ADC linkers; Disulfide-containing payload-module assembly; Antibody–carrier conjugation studies; Copper-free click chemistry. Customization available.

n = 4–48 · 25 Catalog Nos.View Series →

DBCO-PEG-Hydrazide

Dibenzocyclooctyne-functionalized discrete poly(ethylene glycol)-hydrazide (DBCO-PEG-Hydrazide) is an ADC linker intermediate containing a defined-length PEG spacer. It contains a dibenzocyclooctyne (DBCO) reactive terminus and a hydrazide group. Discrete chain lengths with different degrees of polymerization are available. The strained DBCO alkyne can undergo copper-free click reactions with azides, enabling attachment to molecules or materials with preinstalled azide sites. The hydrazide at the other end can form hydrazone linkages with aldehydes or ketones, allowing carbonyl capture and reactions at the other terminus to be performed sequentially. Applications: Acid-responsive hydrazone linkers; Carbonyl-containing payload conjugation; ADC module synthesis; Copper-free click chemistry. Customization available.

n = 4–48 · 25 Catalog Nos.View Series →

BCN-PEG-Val-Cit-PAB-OH

Bicyclononyne-functionalized discrete poly(ethylene glycol)-valyl-citrulline-p-aminobenzyl alcohol (BCN-PEG-Val-Cit-PAB-OH) is an ADC linker intermediate containing a defined-length PEG spacer. It contains a bicyclononyne (BCN) reactive terminus and a valine–citrulline dipeptide. Discrete chain lengths with different degrees of polymerization are available. BCN is a strained alkyne that can undergo copper-free cycloaddition with azides, allowing comparisons of different strained-alkyne conjugation termini. The valine–citrulline dipeptide provides a sequence variable for studies of protease-cleavable linkers. The PAB spacer links peptide cleavage to the subsequent self-immolation process. The PAB hydroxyl group retains a synthetic handle for subsequent activation and payload derivatization. Applications: ADC linker and payload-precursor synthesis; Valine–citrulline dipeptide cleavage studies; Modular antibody conjugation; Strain-promoted click conjugation. Customization available.

n = 4–48 · 25 Catalog Nos.View Series →

BCN-PEG-Val-Cit-PAB-PNP

Bicyclononyne-functionalized discrete poly(ethylene glycol)-valyl-citrulline-p-aminobenzyl p-nitrophenyl carbonate (BCN-PEG-Val-Cit-PAB-PNP) is an ADC linker intermediate containing a defined-length PEG spacer. It contains a bicyclononyne (BCN) reactive terminus and a valine–citrulline dipeptide. Discrete chain lengths with different degrees of polymerization are available. BCN is a strained alkyne that can undergo copper-free cycloaddition with azides, allowing comparisons of different strained-alkyne conjugation termini. The valine–citrulline dipeptide provides a sequence variable for studies of protease-cleavable linkers. The PAB spacer links peptide cleavage to the subsequent self-immolation process. The PNP-activated terminus can be further coupled to suitable amine-containing payloads. Applications: ADC linker and payload-precursor synthesis; Valine–citrulline dipeptide cleavage studies; Modular antibody conjugation; Strain-promoted click conjugation. Customization available.

n = 4–48 · 25 Catalog Nos.View Series →

BCN-PEG-Val-Ala-PAB-OH

Bicyclononyne-functionalized discrete poly(ethylene glycol)-valyl-alanine-p-aminobenzyl alcohol (BCN-PEG-Val-Ala-PAB-OH) is an ADC linker intermediate containing a defined-length PEG spacer. It contains a bicyclononyne (BCN) reactive terminus and a valine–alanine dipeptide. Discrete chain lengths with different degrees of polymerization are available. BCN is a strained alkyne that can undergo copper-free cycloaddition with azides, allowing comparisons of different strained-alkyne conjugation termini. The valine–alanine dipeptide provides a sequence variable for studies of protease-cleavable linkers. The PAB spacer links peptide cleavage to the subsequent self-immolation process. The PAB hydroxyl group retains a synthetic handle for subsequent activation and payload derivatization. Applications: ADC linker and payload-precursor synthesis; Valine–alanine dipeptide cleavage studies; Modular antibody conjugation; Strain-promoted click conjugation. Customization available.

n = 4–48 · 25 Catalog Nos.View Series →

BCN-PEG-Val-Ala-PAB-PNP

Bicyclononyne-functionalized discrete poly(ethylene glycol)-valyl-alanine-p-aminobenzyl p-nitrophenyl carbonate (BCN-PEG-Val-Ala-PAB-PNP) is an ADC linker intermediate containing a defined-length PEG spacer. It contains a bicyclononyne (BCN) reactive terminus and a valine–alanine dipeptide. Discrete chain lengths with different degrees of polymerization are available. BCN is a strained alkyne that can undergo copper-free cycloaddition with azides, allowing comparisons of different strained-alkyne conjugation termini. The valine–alanine dipeptide provides a sequence variable for studies of protease-cleavable linkers. The PAB spacer links peptide cleavage to the subsequent self-immolation process. The PNP-activated terminus can be further coupled to suitable amine-containing payloads. Applications: ADC linker and payload-precursor synthesis; Valine–alanine dipeptide cleavage studies; Modular antibody conjugation; Strain-promoted click conjugation. Customization available.

n = 4–48 · 25 Catalog Nos.View Series →

BCN-PEG-GGFG-COOH

Bicyclononyne-functionalized discrete poly(ethylene glycol)-glycyl-glycyl-phenylalanyl-glycine-carboxylic acid (BCN-PEG-GGFG-COOH) is an ADC linker intermediate containing a defined-length PEG spacer. It contains a bicyclononyne (BCN) reactive terminus and a glycine–glycine–phenylalanine–glycine tetrapeptide. Discrete chain lengths with different degrees of polymerization are available. BCN is a strained alkyne that can undergo copper-free cycloaddition with azides, allowing comparisons of different strained-alkyne conjugation termini. The glycine–glycine–phenylalanine–glycine tetrapeptide provides a sequence variable for studies of protease-cleavable linkers. The terminal carboxyl group can be activated for coupling with amine-containing modules. Applications: ADC linker and payload-precursor synthesis; Glycine–glycine–phenylalanine–glycine tetrapeptide cleavage studies; Modular antibody conjugation; Strain-promoted click conjugation. Customization available.

n = 4–48 · 25 Catalog Nos.View Series →

BCN-PEG-GFLG-COOH

Bicyclononyne-functionalized discrete poly(ethylene glycol)-glycyl-phenylalanyl-leucyl-glycine-carboxylic acid (BCN-PEG-GFLG-COOH) is an ADC linker intermediate containing a defined-length PEG spacer. It contains a bicyclononyne (BCN) reactive terminus and a glycine–phenylalanine–leucine–glycine tetrapeptide. Discrete chain lengths with different degrees of polymerization are available. BCN is a strained alkyne that can undergo copper-free cycloaddition with azides, allowing comparisons of different strained-alkyne conjugation termini. The glycine–phenylalanine–leucine–glycine tetrapeptide provides a sequence variable for studies of protease-cleavable linkers. The terminal carboxyl group can be activated for coupling with amine-containing modules. Applications: ADC linker and payload-precursor synthesis; Glycine–phenylalanine–leucine–glycine tetrapeptide cleavage studies; Modular antibody conjugation; Strain-promoted click conjugation. Customization available.

n = 4–48 · 25 Catalog Nos.View Series →

BCN-PEG-Glu-Val-Cit-PAB-OH

Bicyclononyne-functionalized discrete poly(ethylene glycol)-glutamyl-valyl-citrulline-p-aminobenzyl alcohol (BCN-PEG-Glu-Val-Cit-PAB-OH) is an ADC linker intermediate containing a defined-length PEG spacer. It contains a bicyclononyne (BCN) reactive terminus and a glutamic acid–valine–citrulline tripeptide. Discrete chain lengths with different degrees of polymerization are available. BCN is a strained alkyne that can undergo copper-free cycloaddition with azides, allowing comparisons of different strained-alkyne conjugation termini. The glutamic acid–valine–citrulline tripeptide provides a sequence variable for studies of protease-cleavable linkers. The PAB spacer links peptide cleavage to the subsequent self-immolation process. The PAB hydroxyl group retains a synthetic handle for subsequent activation and payload derivatization. Applications: ADC linker and payload-precursor synthesis; Glutamic acid–valine–citrulline tripeptide cleavage studies; Modular antibody conjugation; Strain-promoted click conjugation. Customization available.

n = 4–48 · 25 Catalog Nos.View Series →

BCN-PEG-Ala-Ala-Asn-PAB-OH

Bicyclononyne-functionalized discrete poly(ethylene glycol)-alanyl-alanyl-asparagine-p-aminobenzyl alcohol (BCN-PEG-Ala-Ala-Asn-PAB-OH) is an ADC linker intermediate containing a defined-length PEG spacer. It contains a bicyclononyne (BCN) reactive terminus and an alanine–alanine–asparagine tripeptide. Discrete chain lengths with different degrees of polymerization are available. BCN is a strained alkyne that can undergo copper-free cycloaddition with azides, allowing comparisons of different strained-alkyne conjugation termini. The alanine–alanine–asparagine tripeptide provides a sequence variable for studies of protease-cleavable linkers. The PAB spacer links peptide cleavage to the subsequent self-immolation process. The PAB hydroxyl group retains a synthetic handle for subsequent activation and payload derivatization. Applications: ADC linker and payload-precursor synthesis; Alanine–alanine–asparagine tripeptide cleavage studies; Modular antibody conjugation; Strain-promoted click conjugation. Customization available.

n = 4–48 · 25 Catalog Nos.View Series →

BCN-PEG-SS-COOH

Bicyclononyne-functionalized discrete poly(ethylene glycol)-disulfide-carboxylic acid (BCN-PEG-SS-COOH) is an ADC linker intermediate containing a defined-length PEG spacer. It contains a bicyclononyne (BCN) reactive terminus and a disulfide linkage. Discrete chain lengths with different degrees of polymerization are available. BCN is a strained alkyne that can undergo copper-free cycloaddition with azides, allowing comparisons of different strained-alkyne conjugation termini. The disulfide can act as a reduction-responsive linking unit. After activation, the carboxyl group can be used to attach amine-containing payloads or other modules. Applications: Reduction-responsive ADC linkers; Disulfide-containing payload-module assembly; Antibody–carrier conjugation studies; Strain-promoted click conjugation. Customization available.

n = 4–48 · 25 Catalog Nos.View Series →

BCN-PEG-Hydrazide

Bicyclononyne-functionalized discrete poly(ethylene glycol)-hydrazide (BCN-PEG-Hydrazide) is an ADC linker intermediate containing a defined-length PEG spacer. It contains a bicyclononyne (BCN) reactive terminus and a hydrazide group. Discrete chain lengths with different degrees of polymerization are available. BCN is a strained alkyne that can undergo copper-free cycloaddition with azides, allowing comparisons of different strained-alkyne conjugation termini. The hydrazide at the other end can form hydrazone linkages with aldehydes or ketones, allowing carbonyl capture and reactions at the other terminus to be performed sequentially. Applications: Acid-responsive hydrazone linkers; Carbonyl-containing payload conjugation; ADC module synthesis; Strain-promoted click conjugation. Customization available.

n = 4–48 · 25 Catalog Nos.View Series →

TCO-PEG-Val-Cit-PAB-OH

Trans-cyclooctene-functionalized discrete poly(ethylene glycol)-valyl-citrulline-p-aminobenzyl alcohol (TCO-PEG-Val-Cit-PAB-OH) is an ADC linker intermediate containing a defined-length PEG spacer. It contains a trans-cyclooctene (TCO) reactive terminus and a valine–citrulline dipeptide. Discrete chain lengths with different degrees of polymerization are available. Trans-cyclooctene can pair with tetrazines in inverse-electron-demand Diels–Alder reactions for assembly of bioorthogonal modules. The valine–citrulline dipeptide provides a sequence variable for studies of protease-cleavable linkers. The PAB spacer links peptide cleavage to the subsequent self-immolation process. The PAB hydroxyl group retains a synthetic handle for subsequent activation and payload derivatization. Applications: ADC linker and payload-precursor synthesis; Valine–citrulline dipeptide cleavage studies; Modular antibody conjugation; Tetrazine-paired bioorthogonal ligation. Customization available.

n = 4–48 · 25 Catalog Nos.View Series →

TCO-PEG-Val-Cit-PAB-PNP

Trans-cyclooctene-functionalized discrete poly(ethylene glycol)-valyl-citrulline-p-aminobenzyl p-nitrophenyl carbonate (TCO-PEG-Val-Cit-PAB-PNP) is an ADC linker intermediate containing a defined-length PEG spacer. It contains a trans-cyclooctene (TCO) reactive terminus and a valine–citrulline dipeptide. Discrete chain lengths with different degrees of polymerization are available. Trans-cyclooctene can pair with tetrazines in inverse-electron-demand Diels–Alder reactions for assembly of bioorthogonal modules. The valine–citrulline dipeptide provides a sequence variable for studies of protease-cleavable linkers. The PAB spacer links peptide cleavage to the subsequent self-immolation process. The PNP-activated terminus can be further coupled to suitable amine-containing payloads. Applications: ADC linker and payload-precursor synthesis; Valine–citrulline dipeptide cleavage studies; Modular antibody conjugation; Tetrazine-paired bioorthogonal ligation. Customization available.

n = 4–48 · 25 Catalog Nos.View Series →

TCO-PEG-Val-Ala-PAB-OH

Trans-cyclooctene-functionalized discrete poly(ethylene glycol)-valyl-alanine-p-aminobenzyl alcohol (TCO-PEG-Val-Ala-PAB-OH) is an ADC linker intermediate containing a defined-length PEG spacer. It contains a trans-cyclooctene (TCO) reactive terminus and a valine–alanine dipeptide. Discrete chain lengths with different degrees of polymerization are available. Trans-cyclooctene can pair with tetrazines in inverse-electron-demand Diels–Alder reactions for assembly of bioorthogonal modules. The valine–alanine dipeptide provides a sequence variable for studies of protease-cleavable linkers. The PAB spacer links peptide cleavage to the subsequent self-immolation process. The PAB hydroxyl group retains a synthetic handle for subsequent activation and payload derivatization. Applications: ADC linker and payload-precursor synthesis; Valine–alanine dipeptide cleavage studies; Modular antibody conjugation; Tetrazine-paired bioorthogonal ligation. Customization available.

n = 4–48 · 25 Catalog Nos.View Series →

TCO-PEG-Val-Ala-PAB-PNP

Trans-cyclooctene-functionalized discrete poly(ethylene glycol)-valyl-alanine-p-aminobenzyl p-nitrophenyl carbonate (TCO-PEG-Val-Ala-PAB-PNP) is an ADC linker intermediate containing a defined-length PEG spacer. It contains a trans-cyclooctene (TCO) reactive terminus and a valine–alanine dipeptide. Discrete chain lengths with different degrees of polymerization are available. Trans-cyclooctene can pair with tetrazines in inverse-electron-demand Diels–Alder reactions for assembly of bioorthogonal modules. The valine–alanine dipeptide provides a sequence variable for studies of protease-cleavable linkers. The PAB spacer links peptide cleavage to the subsequent self-immolation process. The PNP-activated terminus can be further coupled to suitable amine-containing payloads. Applications: ADC linker and payload-precursor synthesis; Valine–alanine dipeptide cleavage studies; Modular antibody conjugation; Tetrazine-paired bioorthogonal ligation. Customization available.

n = 4–48 · 25 Catalog Nos.View Series →

TCO-PEG-GGFG-COOH

Trans-cyclooctene-functionalized discrete poly(ethylene glycol)-glycyl-glycyl-phenylalanyl-glycine-carboxylic acid (TCO-PEG-GGFG-COOH) is an ADC linker intermediate containing a defined-length PEG spacer. It contains a trans-cyclooctene (TCO) reactive terminus and a glycine–glycine–phenylalanine–glycine tetrapeptide. Discrete chain lengths with different degrees of polymerization are available. Trans-cyclooctene can pair with tetrazines in inverse-electron-demand Diels–Alder reactions for assembly of bioorthogonal modules. The glycine–glycine–phenylalanine–glycine tetrapeptide provides a sequence variable for studies of protease-cleavable linkers. The terminal carboxyl group can be activated for coupling with amine-containing modules. Applications: ADC linker and payload-precursor synthesis; Glycine–glycine–phenylalanine–glycine tetrapeptide cleavage studies; Modular antibody conjugation; Tetrazine-paired bioorthogonal ligation. Customization available.

n = 4–48 · 25 Catalog Nos.View Series →

TCO-PEG-GFLG-COOH

Trans-cyclooctene-functionalized discrete poly(ethylene glycol)-glycyl-phenylalanyl-leucyl-glycine-carboxylic acid (TCO-PEG-GFLG-COOH) is an ADC linker intermediate containing a defined-length PEG spacer. It contains a trans-cyclooctene (TCO) reactive terminus and a glycine–phenylalanine–leucine–glycine tetrapeptide. Discrete chain lengths with different degrees of polymerization are available. Trans-cyclooctene can pair with tetrazines in inverse-electron-demand Diels–Alder reactions for assembly of bioorthogonal modules. The glycine–phenylalanine–leucine–glycine tetrapeptide provides a sequence variable for studies of protease-cleavable linkers. The terminal carboxyl group can be activated for coupling with amine-containing modules. Applications: ADC linker and payload-precursor synthesis; Glycine–phenylalanine–leucine–glycine tetrapeptide cleavage studies; Modular antibody conjugation; Tetrazine-paired bioorthogonal ligation. Customization available.

n = 4–48 · 25 Catalog Nos.View Series →

TCO-PEG-Glu-Val-Cit-PAB-OH

Trans-cyclooctene-functionalized discrete poly(ethylene glycol)-glutamyl-valyl-citrulline-p-aminobenzyl alcohol (TCO-PEG-Glu-Val-Cit-PAB-OH) is an ADC linker intermediate containing a defined-length PEG spacer. It contains a trans-cyclooctene (TCO) reactive terminus and a glutamic acid–valine–citrulline tripeptide. Discrete chain lengths with different degrees of polymerization are available. Trans-cyclooctene can pair with tetrazines in inverse-electron-demand Diels–Alder reactions for assembly of bioorthogonal modules. The glutamic acid–valine–citrulline tripeptide provides a sequence variable for studies of protease-cleavable linkers. The PAB spacer links peptide cleavage to the subsequent self-immolation process. The PAB hydroxyl group retains a synthetic handle for subsequent activation and payload derivatization. Applications: ADC linker and payload-precursor synthesis; Glutamic acid–valine–citrulline tripeptide cleavage studies; Modular antibody conjugation; Tetrazine-paired bioorthogonal ligation. Customization available.

n = 4–48 · 25 Catalog Nos.View Series →

TCO-PEG-Ala-Ala-Asn-PAB-OH

Trans-cyclooctene-functionalized discrete poly(ethylene glycol)-alanyl-alanyl-asparagine-p-aminobenzyl alcohol (TCO-PEG-Ala-Ala-Asn-PAB-OH) is an ADC linker intermediate containing a defined-length PEG spacer. It contains a trans-cyclooctene (TCO) reactive terminus and an alanine–alanine–asparagine tripeptide. Discrete chain lengths with different degrees of polymerization are available. Trans-cyclooctene can pair with tetrazines in inverse-electron-demand Diels–Alder reactions for assembly of bioorthogonal modules. The alanine–alanine–asparagine tripeptide provides a sequence variable for studies of protease-cleavable linkers. The PAB spacer links peptide cleavage to the subsequent self-immolation process. The PAB hydroxyl group retains a synthetic handle for subsequent activation and payload derivatization. Applications: ADC linker and payload-precursor synthesis; Alanine–alanine–asparagine tripeptide cleavage studies; Modular antibody conjugation; Tetrazine-paired bioorthogonal ligation. Customization available.

n = 4–48 · 25 Catalog Nos.View Series →

TCO-PEG-SS-COOH

Trans-cyclooctene-functionalized discrete poly(ethylene glycol)-disulfide-carboxylic acid (TCO-PEG-SS-COOH) is an ADC linker intermediate containing a defined-length PEG spacer. It contains a trans-cyclooctene (TCO) reactive terminus and a disulfide linkage. Discrete chain lengths with different degrees of polymerization are available. Trans-cyclooctene can pair with tetrazines in inverse-electron-demand Diels–Alder reactions for assembly of bioorthogonal modules. The disulfide can act as a reduction-responsive linking unit. After activation, the carboxyl group can be used to attach amine-containing payloads or other modules. Applications: Reduction-responsive ADC linkers; Disulfide-containing payload-module assembly; Antibody–carrier conjugation studies; Tetrazine-paired bioorthogonal ligation. Customization available.

n = 4–48 · 25 Catalog Nos.View Series →

TCO-PEG-Hydrazide

Trans-cyclooctene-functionalized discrete poly(ethylene glycol)-hydrazide (TCO-PEG-Hydrazide) is an ADC linker intermediate containing a defined-length PEG spacer. It contains a trans-cyclooctene (TCO) reactive terminus and a hydrazide group. Discrete chain lengths with different degrees of polymerization are available. Trans-cyclooctene can pair with tetrazines in inverse-electron-demand Diels–Alder reactions for assembly of bioorthogonal modules. The hydrazide at the other end can form hydrazone linkages with aldehydes or ketones, allowing carbonyl capture and reactions at the other terminus to be performed sequentially. Applications: Acid-responsive hydrazone linkers; Carbonyl-containing payload conjugation; ADC module synthesis; Tetrazine-paired bioorthogonal ligation. Customization available.

n = 4–48 · 25 Catalog Nos.View Series →

BocNH-PEG-Val-Cit-PAB-OH

tert-butoxycarbonyl-protected amino-functionalized discrete poly(ethylene glycol)-valyl-citrulline-p-aminobenzyl alcohol (BocNH-PEG-Val-Cit-PAB-OH) is an ADC linker intermediate containing a defined-length PEG spacer. It contains a Boc-protected amine reactive terminus and a valine–citrulline dipeptide. Discrete chain lengths with different degrees of polymerization are available. Boc protection separates amine reactions from other synthetic steps. Appropriate deprotection exposes a primary amine for subsequent conjugation. The valine–citrulline dipeptide provides a sequence variable for studies of protease-cleavable linkers. The PAB spacer links peptide cleavage to the subsequent self-immolation process. The PAB hydroxyl group retains a synthetic handle for subsequent activation and payload derivatization. Applications: ADC linker and payload-precursor synthesis; Valine–citrulline dipeptide cleavage studies; Modular antibody conjugation; Protected PEG linkers. Customization available.

n = 4–48 · 25 Catalog Nos.View Series →

BocNH-PEG-Val-Cit-PAB-PNP

tert-butoxycarbonyl-protected amino-functionalized discrete poly(ethylene glycol)-valyl-citrulline-p-aminobenzyl p-nitrophenyl carbonate (BocNH-PEG-Val-Cit-PAB-PNP) is an ADC linker intermediate containing a defined-length PEG spacer. It contains a Boc-protected amine reactive terminus and a valine–citrulline dipeptide. Discrete chain lengths with different degrees of polymerization are available. Boc protection separates amine reactions from other synthetic steps. Appropriate deprotection exposes a primary amine for subsequent conjugation. The valine–citrulline dipeptide provides a sequence variable for studies of protease-cleavable linkers. The PAB spacer links peptide cleavage to the subsequent self-immolation process. The PNP-activated terminus can be further coupled to suitable amine-containing payloads. Applications: ADC linker and payload-precursor synthesis; Valine–citrulline dipeptide cleavage studies; Modular antibody conjugation; Protected PEG linkers. Customization available.

n = 4–48 · 25 Catalog Nos.View Series →

BocNH-PEG-Val-Ala-PAB-OH

tert-butoxycarbonyl-protected amino-functionalized discrete poly(ethylene glycol)-valyl-alanine-p-aminobenzyl alcohol (BocNH-PEG-Val-Ala-PAB-OH) is an ADC linker intermediate containing a defined-length PEG spacer. It contains a Boc-protected amine reactive terminus and a valine–alanine dipeptide. Discrete chain lengths with different degrees of polymerization are available. Boc protection separates amine reactions from other synthetic steps. Appropriate deprotection exposes a primary amine for subsequent conjugation. The valine–alanine dipeptide provides a sequence variable for studies of protease-cleavable linkers. The PAB spacer links peptide cleavage to the subsequent self-immolation process. The PAB hydroxyl group retains a synthetic handle for subsequent activation and payload derivatization. Applications: ADC linker and payload-precursor synthesis; Valine–alanine dipeptide cleavage studies; Modular antibody conjugation; Protected PEG linkers. Customization available.

n = 4–48 · 25 Catalog Nos.View Series →

BocNH-PEG-Val-Ala-PAB-PNP

tert-butoxycarbonyl-protected amino-functionalized discrete poly(ethylene glycol)-valyl-alanine-p-aminobenzyl p-nitrophenyl carbonate (BocNH-PEG-Val-Ala-PAB-PNP) is an ADC linker intermediate containing a defined-length PEG spacer. It contains a Boc-protected amine reactive terminus and a valine–alanine dipeptide. Discrete chain lengths with different degrees of polymerization are available. Boc protection separates amine reactions from other synthetic steps. Appropriate deprotection exposes a primary amine for subsequent conjugation. The valine–alanine dipeptide provides a sequence variable for studies of protease-cleavable linkers. The PAB spacer links peptide cleavage to the subsequent self-immolation process. The PNP-activated terminus can be further coupled to suitable amine-containing payloads. Applications: ADC linker and payload-precursor synthesis; Valine–alanine dipeptide cleavage studies; Modular antibody conjugation; Protected PEG linkers. Customization available.

n = 4–48 · 25 Catalog Nos.View Series →

BocNH-PEG-GGFG-COOH

tert-butoxycarbonyl-protected amino-functionalized discrete poly(ethylene glycol)-glycyl-glycyl-phenylalanyl-glycine-carboxylic acid (BocNH-PEG-GGFG-COOH) is an ADC linker intermediate containing a defined-length PEG spacer. It contains a Boc-protected amine reactive terminus and a glycine–glycine–phenylalanine–glycine tetrapeptide. Discrete chain lengths with different degrees of polymerization are available. Boc protection separates amine reactions from other synthetic steps. Appropriate deprotection exposes a primary amine for subsequent conjugation. The glycine–glycine–phenylalanine–glycine tetrapeptide provides a sequence variable for studies of protease-cleavable linkers. The terminal carboxyl group can be activated for coupling with amine-containing modules. Applications: ADC linker and payload-precursor synthesis; Glycine–glycine–phenylalanine–glycine tetrapeptide cleavage studies; Modular antibody conjugation; Protected PEG linkers. Customization available.

n = 4–48 · 25 Catalog Nos.View Series →

BocNH-PEG-GFLG-COOH

tert-butoxycarbonyl-protected amino-functionalized discrete poly(ethylene glycol)-glycyl-phenylalanyl-leucyl-glycine-carboxylic acid (BocNH-PEG-GFLG-COOH) is an ADC linker intermediate containing a defined-length PEG spacer. It contains a Boc-protected amine reactive terminus and a glycine–phenylalanine–leucine–glycine tetrapeptide. Discrete chain lengths with different degrees of polymerization are available. Boc protection separates amine reactions from other synthetic steps. Appropriate deprotection exposes a primary amine for subsequent conjugation. The glycine–phenylalanine–leucine–glycine tetrapeptide provides a sequence variable for studies of protease-cleavable linkers. The terminal carboxyl group can be activated for coupling with amine-containing modules. Applications: ADC linker and payload-precursor synthesis; Glycine–phenylalanine–leucine–glycine tetrapeptide cleavage studies; Modular antibody conjugation; Protected PEG linkers. Customization available.

n = 4–48 · 25 Catalog Nos.View Series →

BocNH-PEG-Glu-Val-Cit-PAB-OH

tert-butoxycarbonyl-protected amino-functionalized discrete poly(ethylene glycol)-glutamyl-valyl-citrulline-p-aminobenzyl alcohol (BocNH-PEG-Glu-Val-Cit-PAB-OH) is an ADC linker intermediate containing a defined-length PEG spacer. It contains a Boc-protected amine reactive terminus and a glutamic acid–valine–citrulline tripeptide. Discrete chain lengths with different degrees of polymerization are available. Boc protection separates amine reactions from other synthetic steps. Appropriate deprotection exposes a primary amine for subsequent conjugation. The glutamic acid–valine–citrulline tripeptide provides a sequence variable for studies of protease-cleavable linkers. The PAB spacer links peptide cleavage to the subsequent self-immolation process. The PAB hydroxyl group retains a synthetic handle for subsequent activation and payload derivatization. Applications: ADC linker and payload-precursor synthesis; Glutamic acid–valine–citrulline tripeptide cleavage studies; Modular antibody conjugation; Protected PEG linkers. Customization available.

n = 4–48 · 25 Catalog Nos.View Series →

BocNH-PEG-Ala-Ala-Asn-PAB-OH

tert-butoxycarbonyl-protected amino-functionalized discrete poly(ethylene glycol)-alanyl-alanyl-asparagine-p-aminobenzyl alcohol (BocNH-PEG-Ala-Ala-Asn-PAB-OH) is an ADC linker intermediate containing a defined-length PEG spacer. It contains a Boc-protected amine reactive terminus and an alanine–alanine–asparagine tripeptide. Discrete chain lengths with different degrees of polymerization are available. Boc protection separates amine reactions from other synthetic steps. Appropriate deprotection exposes a primary amine for subsequent conjugation. The alanine–alanine–asparagine tripeptide provides a sequence variable for studies of protease-cleavable linkers. The PAB spacer links peptide cleavage to the subsequent self-immolation process. The PAB hydroxyl group retains a synthetic handle for subsequent activation and payload derivatization. Applications: ADC linker and payload-precursor synthesis; Alanine–alanine–asparagine tripeptide cleavage studies; Modular antibody conjugation; Protected PEG linkers. Customization available.

n = 4–48 · 25 Catalog Nos.View Series →

BocNH-PEG-SS-COOH

tert-butoxycarbonyl-protected amino-functionalized discrete poly(ethylene glycol)-disulfide-carboxylic acid (BocNH-PEG-SS-COOH) is an ADC linker intermediate containing a defined-length PEG spacer. It contains a Boc-protected amine reactive terminus and a disulfide linkage. Discrete chain lengths with different degrees of polymerization are available. Boc protection separates amine reactions from other synthetic steps. Appropriate deprotection exposes a primary amine for subsequent conjugation. The disulfide can act as a reduction-responsive linking unit. After activation, the carboxyl group can be used to attach amine-containing payloads or other modules. Applications: Reduction-responsive ADC linkers; Disulfide-containing payload-module assembly; Antibody–carrier conjugation studies; Protected PEG linkers. Customization available.

n = 4–48 · 25 Catalog Nos.View Series →

BocNH-PEG-Hydrazide

tert-butoxycarbonyl-protected amino-functionalized discrete poly(ethylene glycol)-hydrazide (BocNH-PEG-Hydrazide) is an ADC linker intermediate containing a defined-length PEG spacer. It contains a Boc-protected amine reactive terminus and a hydrazide group. Discrete chain lengths with different degrees of polymerization are available. Boc protection separates amine reactions from other synthetic steps. Appropriate deprotection exposes a primary amine for subsequent conjugation. The hydrazide at the other end can form hydrazone linkages with aldehydes or ketones, allowing carbonyl capture and reactions at the other terminus to be performed sequentially. Applications: Acid-responsive hydrazone linkers; Carbonyl-containing payload conjugation; ADC module synthesis; Protected PEG linkers. Customization available.

n = 4–48 · 25 Catalog Nos.View Series →

Alkyne-PEG-Val-Cit-PAB-OH

Terminal alkyne-functionalized discrete poly(ethylene glycol)-valyl-citrulline-p-aminobenzyl alcohol (Alkyne-PEG-Val-Cit-PAB-OH) is an ADC linker intermediate containing a defined-length PEG spacer. It contains a terminal alkyne reactive terminus and a valine–citrulline dipeptide. Discrete chain lengths with different degrees of polymerization are available. The terminal alkyne can undergo suitable copper-catalyzed cycloaddition with azides, linking the PEG spacer to target molecular modules. The valine–citrulline dipeptide provides a sequence variable for studies of protease-cleavable linkers. The PAB spacer links peptide cleavage to the subsequent self-immolation process. The PAB hydroxyl group retains a synthetic handle for subsequent activation and payload derivatization. Applications: ADC linker and payload-precursor synthesis; Valine–citrulline dipeptide cleavage studies; Modular antibody conjugation; Copper-catalyzed azide–alkyne click chemistry. Customization available.

n = 4–48 · 25 Catalog Nos.View Series →

Alkyne-PEG-Val-Cit-PAB-PNP

Terminal alkyne-functionalized discrete poly(ethylene glycol)-valyl-citrulline-p-aminobenzyl p-nitrophenyl carbonate (Alkyne-PEG-Val-Cit-PAB-PNP) is an ADC linker intermediate containing a defined-length PEG spacer. It contains a terminal alkyne reactive terminus and a valine–citrulline dipeptide. Discrete chain lengths with different degrees of polymerization are available. The terminal alkyne can undergo suitable copper-catalyzed cycloaddition with azides, linking the PEG spacer to target molecular modules. The valine–citrulline dipeptide provides a sequence variable for studies of protease-cleavable linkers. The PAB spacer links peptide cleavage to the subsequent self-immolation process. The PNP-activated terminus can be further coupled to suitable amine-containing payloads. Applications: ADC linker and payload-precursor synthesis; Valine–citrulline dipeptide cleavage studies; Modular antibody conjugation; Copper-catalyzed azide–alkyne click chemistry. Customization available.

n = 4–48 · 25 Catalog Nos.View Series →

Alkyne-PEG-Val-Ala-PAB-OH

Terminal alkyne-functionalized discrete poly(ethylene glycol)-valyl-alanine-p-aminobenzyl alcohol (Alkyne-PEG-Val-Ala-PAB-OH) is an ADC linker intermediate containing a defined-length PEG spacer. It contains a terminal alkyne reactive terminus and a valine–alanine dipeptide. Discrete chain lengths with different degrees of polymerization are available. The terminal alkyne can undergo suitable copper-catalyzed cycloaddition with azides, linking the PEG spacer to target molecular modules. The valine–alanine dipeptide provides a sequence variable for studies of protease-cleavable linkers. The PAB spacer links peptide cleavage to the subsequent self-immolation process. The PAB hydroxyl group retains a synthetic handle for subsequent activation and payload derivatization. Applications: ADC linker and payload-precursor synthesis; Valine–alanine dipeptide cleavage studies; Modular antibody conjugation; Copper-catalyzed azide–alkyne click chemistry. Customization available.

n = 4–48 · 25 Catalog Nos.View Series →

Alkyne-PEG-Val-Ala-PAB-PNP

Terminal alkyne-functionalized discrete poly(ethylene glycol)-valyl-alanine-p-aminobenzyl p-nitrophenyl carbonate (Alkyne-PEG-Val-Ala-PAB-PNP) is an ADC linker intermediate containing a defined-length PEG spacer. It contains a terminal alkyne reactive terminus and a valine–alanine dipeptide. Discrete chain lengths with different degrees of polymerization are available. The terminal alkyne can undergo suitable copper-catalyzed cycloaddition with azides, linking the PEG spacer to target molecular modules. The valine–alanine dipeptide provides a sequence variable for studies of protease-cleavable linkers. The PAB spacer links peptide cleavage to the subsequent self-immolation process. The PNP-activated terminus can be further coupled to suitable amine-containing payloads. Applications: ADC linker and payload-precursor synthesis; Valine–alanine dipeptide cleavage studies; Modular antibody conjugation; Copper-catalyzed azide–alkyne click chemistry. Customization available.

n = 4–48 · 25 Catalog Nos.View Series →

Alkyne-PEG-GGFG-COOH

Terminal alkyne-functionalized discrete poly(ethylene glycol)-glycyl-glycyl-phenylalanyl-glycine-carboxylic acid (Alkyne-PEG-GGFG-COOH) is an ADC linker intermediate containing a defined-length PEG spacer. It contains a terminal alkyne reactive terminus and a glycine–glycine–phenylalanine–glycine tetrapeptide. Discrete chain lengths with different degrees of polymerization are available. The terminal alkyne can undergo suitable copper-catalyzed cycloaddition with azides, linking the PEG spacer to target molecular modules. The glycine–glycine–phenylalanine–glycine tetrapeptide provides a sequence variable for studies of protease-cleavable linkers. The terminal carboxyl group can be activated for coupling with amine-containing modules. Applications: ADC linker and payload-precursor synthesis; Glycine–glycine–phenylalanine–glycine tetrapeptide cleavage studies; Modular antibody conjugation; Copper-catalyzed azide–alkyne click chemistry. Customization available.

n = 4–48 · 25 Catalog Nos.View Series →

Alkyne-PEG-GFLG-COOH

Terminal alkyne-functionalized discrete poly(ethylene glycol)-glycyl-phenylalanyl-leucyl-glycine-carboxylic acid (Alkyne-PEG-GFLG-COOH) is an ADC linker intermediate containing a defined-length PEG spacer. It contains a terminal alkyne reactive terminus and a glycine–phenylalanine–leucine–glycine tetrapeptide. Discrete chain lengths with different degrees of polymerization are available. The terminal alkyne can undergo suitable copper-catalyzed cycloaddition with azides, linking the PEG spacer to target molecular modules. The glycine–phenylalanine–leucine–glycine tetrapeptide provides a sequence variable for studies of protease-cleavable linkers. The terminal carboxyl group can be activated for coupling with amine-containing modules. Applications: ADC linker and payload-precursor synthesis; Glycine–phenylalanine–leucine–glycine tetrapeptide cleavage studies; Modular antibody conjugation; Copper-catalyzed azide–alkyne click chemistry. Customization available.

n = 4–48 · 25 Catalog Nos.View Series →

Alkyne-PEG-Glu-Val-Cit-PAB-OH

Terminal alkyne-functionalized discrete poly(ethylene glycol)-glutamyl-valyl-citrulline-p-aminobenzyl alcohol (Alkyne-PEG-Glu-Val-Cit-PAB-OH) is an ADC linker intermediate containing a defined-length PEG spacer. It contains a terminal alkyne reactive terminus and a glutamic acid–valine–citrulline tripeptide. Discrete chain lengths with different degrees of polymerization are available. The terminal alkyne can undergo suitable copper-catalyzed cycloaddition with azides, linking the PEG spacer to target molecular modules. The glutamic acid–valine–citrulline tripeptide provides a sequence variable for studies of protease-cleavable linkers. The PAB spacer links peptide cleavage to the subsequent self-immolation process. The PAB hydroxyl group retains a synthetic handle for subsequent activation and payload derivatization. Applications: ADC linker and payload-precursor synthesis; Glutamic acid–valine–citrulline tripeptide cleavage studies; Modular antibody conjugation; Copper-catalyzed azide–alkyne click chemistry. Customization available.

n = 4–48 · 25 Catalog Nos.View Series →

Alkyne-PEG-Ala-Ala-Asn-PAB-OH

Terminal alkyne-functionalized discrete poly(ethylene glycol)-alanyl-alanyl-asparagine-p-aminobenzyl alcohol (Alkyne-PEG-Ala-Ala-Asn-PAB-OH) is an ADC linker intermediate containing a defined-length PEG spacer. It contains a terminal alkyne reactive terminus and an alanine–alanine–asparagine tripeptide. Discrete chain lengths with different degrees of polymerization are available. The terminal alkyne can undergo suitable copper-catalyzed cycloaddition with azides, linking the PEG spacer to target molecular modules. The alanine–alanine–asparagine tripeptide provides a sequence variable for studies of protease-cleavable linkers. The PAB spacer links peptide cleavage to the subsequent self-immolation process. The PAB hydroxyl group retains a synthetic handle for subsequent activation and payload derivatization. Applications: ADC linker and payload-precursor synthesis; Alanine–alanine–asparagine tripeptide cleavage studies; Modular antibody conjugation; Copper-catalyzed azide–alkyne click chemistry. Customization available.

n = 4–48 · 25 Catalog Nos.View Series →

Alkyne-PEG-SS-COOH

Terminal alkyne-functionalized discrete poly(ethylene glycol)-disulfide-carboxylic acid (Alkyne-PEG-SS-COOH) is an ADC linker intermediate containing a defined-length PEG spacer. It contains a terminal alkyne reactive terminus and a disulfide linkage. Discrete chain lengths with different degrees of polymerization are available. The terminal alkyne can undergo suitable copper-catalyzed cycloaddition with azides, linking the PEG spacer to target molecular modules. The disulfide can act as a reduction-responsive linking unit. After activation, the carboxyl group can be used to attach amine-containing payloads or other modules. Applications: Reduction-responsive ADC linkers; Disulfide-containing payload-module assembly; Antibody–carrier conjugation studies; Copper-catalyzed azide–alkyne click chemistry. Customization available.

n = 4–48 · 25 Catalog Nos.View Series →

Alkyne-PEG-Hydrazide

Terminal alkyne-functionalized discrete poly(ethylene glycol)-hydrazide (Alkyne-PEG-Hydrazide) is an ADC linker intermediate containing a defined-length PEG spacer. It contains a terminal alkyne reactive terminus and a hydrazide group. Discrete chain lengths with different degrees of polymerization are available. The terminal alkyne can undergo suitable copper-catalyzed cycloaddition with azides, linking the PEG spacer to target molecular modules. The hydrazide at the other end can form hydrazone linkages with aldehydes or ketones, allowing carbonyl capture and reactions at the other terminus to be performed sequentially. Applications: Acid-responsive hydrazone linkers; Carbonyl-containing payload conjugation; ADC module synthesis; Copper-catalyzed azide–alkyne click chemistry. Customization available.

n = 4–48 · 25 Catalog Nos.View Series →