N3-PEG-Hydrazide

Azido-functionalized discrete poly(ethylene glycol)-hydrazide (N3-PEG-Hydrazide) is an ADC linker intermediate containing a defined-length PEG spacer. It contains an azide reactive terminus and a hydrazide group. Discrete chain lengths with different degrees of polymerization are available. The azide can undergo copper-catalyzed click reactions with terminal alkynes or copper-free click conjugation with strained alkynes such as DBCO and BCN. The hydrazide at the other end can form hydrazone linkages with aldehydes or ketones, allowing carbonyl capture and reactions at the other terminus to be performed sequentially.

Customization available.