TCO-PEG-CH2CH2COONHS Ester

Alpha-(trans-cyclooctene)-omega-(N-hydroxysuccinimide ester) poly(ethylene glycol) (TCO-PEG-NHS) is a heterobifunctional precision PEG derivative with a defined chain length. The two ends bear trans-cyclooctene (TCO) and N-hydroxysuccinimide ester groups, respectively. Discrete chain lengths with different degrees of polymerization are available. Trans-cyclooctene can pair with tetrazines in inverse-electron-demand Diels–Alder reactions for assembly of bioorthogonal modules. The NHS ester can form amide bonds with primary amines, enabling conjugation to amine-containing small molecules, peptides, proteins, or material surfaces. The two end groups can be coupled sequentially using compatible reactions and appropriate protection strategies, enabling surface immobilization, functional-molecule bridging, and directional spacer synthesis.

Customization available.