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Monofunctional Precision PEG

Monofunctional precision polyethylene glycol is a family of molecular linking materials combining a hydrophilic PEG segment with a single functional terminus. One end is typically capped with a group such as methoxy, while the other can bear a hydroxyl, amine, carboxyl, thiol, activated ester, maleimide, or click-chemistry group to provide suitable modification chemistry for different substrates. Compared with conventional PEG with a broad chain-length distribution, structurally defined precision PEG is particularly useful in research requiring clear molecular composition and reproducible structural design. In biomedical research, these products are commonly used as PEGylation reagents for proteins, peptides, and small-molecule drugs, and as hydrophilic linkers in antibody conjugates, fluorescent probes, and functionalized biomolecules. Introducing a PEG segment into a target molecule enables researchers to study aqueous solubility, steric effects, and interactions with biological interfaces, and to investigate structure–activity relationships and conjugation processes. In materials science, monofunctional precision PEG can be used for nanoparticle surface modification, grafting onto solid interfaces, polymer end-group modification, and hydrophilic coating design. Different end groups accommodate reactions such as amidation, thiol conjugation, and bioorthogonal ligation, providing starting materials for drug delivery, diagnostic analysis, and functional polymer development.

mPEG-OH

Methoxy Poly(ethylene glycol) Alcohol; Poly(ethylene glycol) Monomethyl Ether (mPEG-OH) is a precision PEG derivative with a defined chain length. One end bears a methoxy group. The other end bears a hydroxyl group. Discrete chain lengths with different degrees of polymerization are available. The terminal hydroxyl group can be further modified by esterification, etherification, or other functional-group transformations, enabling the synthesis of functional PEG derivatives and precision molecular linkers. Applications: Precision PEG derivatization; Bioconjugation linker synthesis; Drug modification and functional-molecule conjugation. Customization available.

n = 4–192 · 30 Catalog Nos.View Series →

mPEG-NH2

Methoxy-poly(ethylene glycol)-amine (mPEG-NH2) is a monofunctional precision PEG derivative with a defined chain length. One end bears a methoxy group. The other end bears a primary amine group. Discrete chain lengths with different degrees of polymerization are available. The primary amine can react with activated carboxyl groups or NHS esters to form amide bonds and introduce carboxyl-containing functional moieties. Capping one end defines the direction of derivatization, enabling the hydrophilic PEG segment to be attached to a target molecule and functional linkers of the required length to be constructed. Applications: Amide-based bioconjugation; Peptide and functional small-molecule conjugation; Amino-PEG derivatization. Customization available.

n = 2–192 · 32 Catalog Nos.View Series →

mPEG-SH

Methoxy-poly(ethylene glycol)-thiol (mPEG-SH) is a monofunctional precision PEG derivative with a defined chain length. One end bears a methoxy group. The other end bears a thiol group. Discrete chain lengths with different degrees of polymerization are available. The thiol can add to maleimides or participate in disulfide formation, offering different molecular conjugation routes. Capping one end defines the direction of derivatization, enabling the hydrophilic PEG segment to be attached to a target molecule and functional linkers of the required length to be constructed. Applications: Thiol-selective conjugation; Disulfide-linkage design; Surface anchoring and crosslinked materials. Customization available.

n = 3–192 · 31 Catalog Nos.View Series →

mPEG-Mal

Methoxy-poly(ethylene glycol)-maleimide (mPEG-MAL) is a monofunctional precision PEG derivative with a defined chain length. One end bears a methoxy group. The other end bears a maleimide group. Discrete chain lengths with different degrees of polymerization are available. The maleimide can add to cysteine thiols or other thiolated modules, providing a handle for conjugation at thiol sites. Capping one end defines the direction of derivatization, enabling the hydrophilic PEG segment to be attached to a target molecule and functional linkers of the required length to be constructed. Applications: Cysteine-site modification; Thiol-selective bioconjugation; Protein–functional material conjugation. Customization available.

n = 3–192 · 31 Catalog Nos.View Series →

mPEG-N3

Methoxy-poly(ethylene glycol)-azido (mPEG-N3) is a monofunctional precision PEG derivative with a defined chain length. One end bears a methoxy group. The other end bears an azide group. Discrete chain lengths with different degrees of polymerization are available. The azide can undergo copper-catalyzed click reactions with terminal alkynes or copper-free click conjugation with strained alkynes such as DBCO and BCN. Capping one end defines the direction of derivatization, enabling the hydrophilic PEG segment to be attached to a target molecule and functional linkers of the required length to be constructed. Applications: Azide click chemistry; Bioorthogonal conjugation; Bifunctional molecular linker synthesis. Customization available.

n = 3–192 · 31 Catalog Nos.View Series →

mPEG-NHBoc

Methoxy-poly(ethylene glycol)-tert-butoxycarbonyl-protected amino (mPEG-BocNH) is a monofunctional precision PEG derivative with a defined chain length. One end bears a methoxy group. The other end bears a Boc-protected amine group. Discrete chain lengths with different degrees of polymerization are available. Boc protection separates amine reactions from other synthetic steps. Appropriate deprotection exposes a primary amine for subsequent conjugation. Capping one end defines the direction of derivatization, enabling the hydrophilic PEG segment to be attached to a target molecule and functional linkers of the required length to be constructed. Applications: Protected PEG linkers; Sequential bioconjugation synthesis; Primary-amine precursor construction. Customization available.

n = 4–192 · 30 Catalog Nos.View Series →

mPEG-NHFmoc

Methoxy-poly(ethylene glycol)-fluorenylmethoxycarbonyl-protected amino (mPEG-FmocNH) is a monofunctional precision PEG derivative with a defined chain length. One end bears a methoxy group. The other end bears a Fmoc-protected amine group. Discrete chain lengths with different degrees of polymerization are available. Fmoc protection facilitates sequential conjugation. Amine coupling can follow deprotection under conditions compatible with the target system. Capping one end defines the direction of derivatization, enabling the hydrophilic PEG segment to be attached to a target molecule and functional linkers of the required length to be constructed. Applications: Orthogonal protection and linker synthesis; Peptide conjugation intermediates; Sequential amine functionalization. Customization available.

n = 4–192 · 30 Catalog Nos.View Series →

mPEG-NHCbz

Methoxy-poly(ethylene glycol)-benzyloxycarbonyl-protected amino (mPEG-CbzNH) is a monofunctional precision PEG derivative with a defined chain length. One end bears a methoxy group. The other end bears a Cbz-protected amine group. Discrete chain lengths with different degrees of polymerization are available. The Cbz-protected end retains a releasable amine precursor, allowing amine coupling and transformations at the other terminus to be performed sequentially. Capping one end defines the direction of derivatization, enabling the hydrophilic PEG segment to be attached to a target molecule and functional linkers of the required length to be constructed. Applications: Protected amino linkers; Sequential end-group transformations; Functional molecular module synthesis. Customization available.

n = 4–192 · 30 Catalog Nos.View Series →

mPEG-ONH2

Methoxy-poly(ethylene glycol)-aminooxy (mPEG-ONH2) is a monofunctional precision PEG derivative with a defined chain length. One end bears a methoxy group. The other end bears an aminooxy group. Discrete chain lengths with different degrees of polymerization are available. The aminooxy group can condense with aldehydes or ketones to form oxime bonds, providing a conjugation route for carbonyl-containing molecules and carriers. Capping one end defines the direction of derivatization, enabling the hydrophilic PEG segment to be attached to a target molecule and functional linkers of the required length to be constructed. Applications: Oxime ligation; Carbonyl-site labeling; Glycan and functional-probe conjugation. Customization available.

n = 4–192 · 30 Catalog Nos.View Series →

mPEG-OTs

Methoxy-poly(ethylene glycol)-p-toluenesulfonate (mPEG-OTs) is a monofunctional precision PEG derivative with a defined chain length. One end bears a methoxy group. The other end bears a tosylate group. Discrete chain lengths with different degrees of polymerization are available. The tosylate acts as a leaving group, enabling nitrogen- or sulfur-containing functional moieties to be introduced by nucleophilic substitution. Capping one end defines the direction of derivatization, enabling the hydrophilic PEG segment to be attached to a target molecule and functional linkers of the required length to be constructed. Applications: PEG end-group conversion; Nucleophilic substitution intermediates; Linker extension. Customization available.

n = 4–192 · 30 Catalog Nos.View Series →

mPEG-OMs

Methoxy-poly(ethylene glycol)-methanesulfonate (mPEG-OMs) is a monofunctional precision PEG derivative with a defined chain length. One end bears a methoxy group. The other end bears a mesylate group. Discrete chain lengths with different degrees of polymerization are available. The mesylate provides a handle for nucleophilic substitution, allowing chain-segment construction and installation of the final functional terminus to be performed separately. Capping one end defines the direction of derivatization, enabling the hydrophilic PEG segment to be attached to a target molecule and functional linkers of the required length to be constructed. Applications: End-group nucleophilic substitution; Functional PEG synthesis; Chain-extension intermediates. Customization available.

n = 4–192 · 30 Catalog Nos.View Series →

mPEG-Cl

Methoxy-poly(ethylene glycol)-chloro (mPEG-Cl) is a monofunctional precision PEG derivative with a defined chain length. One end bears a methoxy group. The other end bears a chloro group group. Discrete chain lengths with different degrees of polymerization are available. The chloro terminus can serve as a precursor for suitable nucleophilic substitution reactions to introduce target functional moieties. Capping one end defines the direction of derivatization, enabling the hydrophilic PEG segment to be attached to a target molecule and functional linkers of the required length to be constructed. Applications: Halogenated PEG derivatization; Nucleophilic substitution intermediates; Chain-segment conjugation studies. Customization available.

n = 4–192 · 30 Catalog Nos.View Series →

mPEG-Br

Methoxy-poly(ethylene glycol)-bromo (mPEG-Br) is a monofunctional precision PEG derivative with a defined chain length. One end bears a methoxy group. The other end bears a bromo group group. Discrete chain lengths with different degrees of polymerization are available. The bromo terminus retains a handle for subsequent nucleophilic substitution, facilitating the introduction of nitrogen- or sulfur-containing linking moieties. Capping one end defines the direction of derivatization, enabling the hydrophilic PEG segment to be attached to a target molecule and functional linkers of the required length to be constructed. Applications: Bromo end-group conversion; Linker synthesis; Installation of functional moieties. Customization available.

n = 2–192 · 32 Catalog Nos.View Series →

mPEG-I

Methoxy-poly(ethylene glycol)-iodo (mPEG-I) is a monofunctional precision PEG derivative with a defined chain length. One end bears a methoxy group. The other end bears an iodo group group. Discrete chain lengths with different degrees of polymerization are available. The iodo terminus can be used in suitable nucleophilic substitution routes, enabling comparisons of different halogenated linker precursors and their derivatives. Capping one end defines the direction of derivatization, enabling the hydrophilic PEG segment to be attached to a target molecule and functional linkers of the required length to be constructed. Applications: Iodo-PEG intermediates; Terminal substitution reactions; Functional-molecule synthesis. Customization available.

n = 4–192 · 30 Catalog Nos.View Series →

mPEG-OAc

Methoxy-poly(ethylene glycol)-acetoxy (mPEG-OAc) is a monofunctional precision PEG derivative with a defined chain length. One end bears a methoxy group. The other end bears a acetoxy group. Discrete chain lengths with different degrees of polymerization are available. The acetate temporarily masks the hydroxyl group. Appropriate deprotection restores the opportunity for further hydroxyl derivatization. Capping one end defines the direction of derivatization, enabling the hydrophilic PEG segment to be attached to a target molecule and functional linkers of the required length to be constructed. Applications: Hydroxyl protection and deprotection; Sequential PEG derivatization; Acetate-linkage structure studies. Customization available.

n = 4–192 · 30 Catalog Nos.View Series →

mPEG-Acrylate

Methoxy-poly(ethylene glycol)-acrylate (mPEG-Acrylate) is a monofunctional precision PEG derivative with a defined chain length. One end bears a methoxy group. The other end bears an acrylate group. Discrete chain lengths with different degrees of polymerization are available. The acrylate double bond can participate in radical polymerization or suitable thiol addition reactions to introduce a polymerizable PEG segment. Capping one end defines the direction of derivatization, enabling the hydrophilic PEG segment to be attached to a target molecule and functional linkers of the required length to be constructed. Applications: Polymerizable PEG monomers; Thiol-addition conjugation; Hydrogel and crosslinked-network studies. Customization available.

n = 4–192 · 30 Catalog Nos.View Series →

mPEG-Methacrylate

Methoxy-poly(ethylene glycol)-methacrylate (mPEG-Methacrylate) is a monofunctional precision PEG derivative with a defined chain length. One end bears a methoxy group. The other end bears a methacrylate group. Discrete chain lengths with different degrees of polymerization are available. The methacrylate can undergo radical polymerization or copolymerization, covalently incorporating the PEG segment into polymer materials. Capping one end defines the direction of derivatization, enabling the hydrophilic PEG segment to be attached to a target molecule and functional linkers of the required length to be constructed. Applications: Functional PEG monomers; Hydrophilic copolymer materials; Crosslinked networks and surface grafting. Customization available.

n = 4–192 · 30 Catalog Nos.View Series →

mPEG-VinylEther

Methoxy-poly(ethylene glycol)-vinyl ether (mPEG-VinylEther) is a monofunctional precision PEG derivative with a defined chain length. One end bears a methoxy group. The other end bears a vinyl ether group. Discrete chain lengths with different degrees of polymerization are available. The vinyl ether retains a double bond available for polymerization or addition in compatible chain-segment polymerization and functionalization routes. Capping one end defines the direction of derivatization, enabling the hydrophilic PEG segment to be attached to a target molecule and functional linkers of the required length to be constructed. Applications: Vinyl ether polymerization; Reactive hydrophilic segments; Functional-material synthesis. Customization available.

n = 4–192 · 30 Catalog Nos.View Series →

mPEG-Allyl

Methoxy-poly(ethylene glycol)-allyl ether (mPEG-Allyl) is a monofunctional precision PEG derivative with a defined chain length. One end bears a methoxy group. The other end bears a allyl ether group. Discrete chain lengths with different degrees of polymerization are available. The allyl group can participate in thiol–ene reactions or suitable alkene transformations, providing a conjugation handle for thiol-containing modules. Capping one end defines the direction of derivatization, enabling the hydrophilic PEG segment to be attached to a target molecule and functional linkers of the required length to be constructed. Applications: Thiol–ene conjugation; Alkenyl-functional PEG; Crosslinked materials and surface modification. Customization available.

n = 4–192 · 30 Catalog Nos.View Series →

mPEG-Propargyl

Methoxy-poly(ethylene glycol)-propargyl ether (mPEG-Propargyl) is a monofunctional precision PEG derivative with a defined chain length. One end bears a methoxy group. The other end bears a propargyl ether group. Discrete chain lengths with different degrees of polymerization are available. The propargyl ether retains a terminal alkyne and an ether linkage, enabling target functional moieties to be introduced through azide–alkyne click reactions. Capping one end defines the direction of derivatization, enabling the hydrophilic PEG segment to be attached to a target molecule and functional linkers of the required length to be constructed. Applications: Propargyl-PEG derivatization; Azide–alkyne click assembly; Ether-linker synthesis. Customization available.

n = 3–192 · 31 Catalog Nos.View Series →

mPEG-CH2COOH

Methoxy-poly(ethylene glycol)-carboxymethyl (mPEG-CH2COOH) is a monofunctional precision PEG derivative with a defined chain length. One end bears a methoxy group. The other end bears a carboxymethyl group. Discrete chain lengths with different degrees of polymerization are available. The carboxymethyl group can be activated for coupling with primary amines. Its single methylene group defines the local connection between the reactive carboxyl group and the polyether chain. Capping one end defines the direction of derivatization, enabling the hydrophilic PEG segment to be attached to a target molecule and functional linkers of the required length to be constructed. Applications: Carboxymethyl-PEG derivatization; Amide-linker synthesis; Local spacing studies at reactive termini. Customization available.

n = 2–192 · 32 Catalog Nos.View Series →

mPEG-CH2CH2COOH

Methoxy-poly(ethylene glycol)-carboxyethyl (mPEG-CH2CH2COOH) is a monofunctional precision PEG derivative with a defined chain length. One end bears a methoxy group. The other end bears a carboxyethyl group. Discrete chain lengths with different degrees of polymerization are available. The carboxyethyl group can be activated to couple with amine-containing components. Its two methylene groups provide a local spacer distinct from a carboxymethyl linker. Capping one end defines the direction of derivatization, enabling the hydrophilic PEG segment to be attached to a target molecule and functional linkers of the required length to be constructed. Applications: Extended carboxylic acid linkers; Amine-containing ligand conjugation; Local spacer structure–activity comparisons. Customization available.

n = 3–192 · 31 Catalog Nos.View Series →

mPEG-CH2COOtBu

Methoxy-poly(ethylene glycol)-tert-butyl-protected carboxymethyl (mPEG-CH2COOtBu) is a monofunctional precision PEG derivative with a defined chain length. One end bears a methoxy group. The other end bears a tert-butyl-ester-protected carboxymethyl group. Discrete chain lengths with different degrees of polymerization are available. The tert-butyl ester temporarily protects a carboxyl precursor. Appropriate acidic deprotection enables subsequent carboxyl activation and amide coupling. Capping one end defines the direction of derivatization, enabling the hydrophilic PEG segment to be attached to a target molecule and functional linkers of the required length to be constructed. Applications: Protected carboxylic acid linkers; Sequential end-group conjugation; PEG synthetic intermediates. Customization available.

n = 4–192 · 30 Catalog Nos.View Series →

mPEG-CH2COOMe

Methoxy-poly(ethylene glycol)-methyl-protected carboxymethyl (mPEG-CH2COOMe) is a monofunctional precision PEG derivative with a defined chain length. One end bears a methoxy group. The other end bears a methyl-ester-protected carboxymethyl group. Discrete chain lengths with different degrees of polymerization are available. The methyl ester remains available for subsequent ester transformations, allowing a conjugatable carboxyl group to be introduced after other linking steps. Capping one end defines the direction of derivatization, enabling the hydrophilic PEG segment to be attached to a target molecule and functional linkers of the required length to be constructed. Applications: Carboxylic acid precursor synthesis; Sequential PEG derivatization; Ester-linker conversion. Customization available.

n = 4–192 · 30 Catalog Nos.View Series →

mPEG-CH2COONHS Ester

Methoxy-poly(ethylene glycol)-carboxymethyl N-hydroxysuccinimide ester (mPEG-CH2CONHS) is a monofunctional precision PEG derivative with a defined chain length. One end bears a methoxy group. The other end bears a carboxymethyl NHS ester group. Discrete chain lengths with different degrees of polymerization are available. The carboxymethyl NHS ester can directly couple to primary-amine-containing components, enabling comparisons of the short spacing between the activated site and the polyether chain. Capping one end defines the direction of derivatization, enabling the hydrophilic PEG segment to be attached to a target molecule and functional linkers of the required length to be constructed. Applications: Primary-amine labeling and conjugation; Carboxymethyl activated-ester linkers; Protein surface modification. Customization available.

n = 4–192 · 30 Catalog Nos.View Series →

mPEG-CH2CH2COONHS Ester

Methoxy-poly(ethylene glycol)-carboxyethyl N-hydroxysuccinimide ester (mPEG-CH2CH2CONHS) is a monofunctional precision PEG derivative with a defined chain length. One end bears a methoxy group. The other end bears a carboxyethyl NHS ester group. Discrete chain lengths with different degrees of polymerization are available. The carboxyethyl NHS ester can couple to primary amines while retaining an extended local spacer for designing different conjugation distances. Capping one end defines the direction of derivatization, enabling the hydrophilic PEG segment to be attached to a target molecule and functional linkers of the required length to be constructed. Applications: Primary-amine-reactive linkers; Extended activated-ester synthesis; Spacer-structure comparisons. Customization available.

n = 1–192 · 33 Catalog Nos.View Series →

mPEG-CH2CONHNH2

Methoxy-poly(ethylene glycol)-carboxymethyl hydrazide (mPEG-CH2CONHNH2) is a monofunctional precision PEG derivative with a defined chain length. One end bears a methoxy group. The other end bears a carboxymethyl hydrazide group. Discrete chain lengths with different degrees of polymerization are available. The hydrazide can condense with aldehydes or ketones to form hydrazone bonds. The carboxymethyl moiety retains a short spacer to the polyether chain. Capping one end defines the direction of derivatization, enabling the hydrophilic PEG segment to be attached to a target molecule and functional linkers of the required length to be constructed. Applications: Carbonyl capture; Hydrazone-linker synthesis; Acid-responsive linkage model studies. Customization available.

n = 4–192 · 30 Catalog Nos.View Series →

mPEG-Glycidyl

Methoxy-poly(ethylene glycol)-glycidyl ether (mPEG-Glycidyl) is a monofunctional precision PEG derivative with a defined chain length. One end bears a methoxy group. The other end bears a glycidyl ether group. Discrete chain lengths with different degrees of polymerization are available. The epoxide can undergo ring-opening addition with suitable nucleophiles, such as amines or thiols, for subsequent segment linking and material crosslinking. Capping one end defines the direction of derivatization, enabling the hydrophilic PEG segment to be attached to a target molecule and functional linkers of the required length to be constructed. Applications: Epoxide ring-opening conjugation; Amine- and thiol-containing material conjugation; Functional polyether synthesis. Customization available.

n = 4–192 · 30 Catalog Nos.View Series →

mPEG-OPNP

Methoxy-poly(ethylene glycol)-p-nitrophenyl carbonate (mPEG-OPNP) is a monofunctional precision PEG derivative with a defined chain length. One end bears a methoxy group. The other end bears a p-nitrophenyl carbonate group. Discrete chain lengths with different degrees of polymerization are available. The activated carbonate can react with amine-containing components to form carbamate linkages, providing a linkage distinct from a conventional amide bond. Capping one end defines the direction of derivatization, enabling the hydrophilic PEG segment to be attached to a target molecule and functional linkers of the required length to be constructed. Applications: Carbamate conjugation; Amine modification in proteins or small molecules; Activated PEG intermediates. Customization available.

n = 4–192 · 30 Catalog Nos.View Series →

mPEG-OSuc

Methoxy-poly(ethylene glycol)-succinate half-ester (mPEG-OSuc) is a monofunctional precision PEG derivative with a defined chain length. One end bears a methoxy group. The other end bears a succinate monoester group. Discrete chain lengths with different degrees of polymerization are available. The succinate monoester retains an ester bond and a free carboxyl group. The latter can be activated for coupling with amine-containing components. Capping one end defines the direction of derivatization, enabling the hydrophilic PEG segment to be attached to a target molecule and functional linkers of the required length to be constructed. Applications: Ester-containing PEG linkers; Activated-carboxyl coupling; Derivatizable intermediates. Customization available.

n = 4–192 · 30 Catalog Nos.View Series →

mPEG-NHMe

Methoxy-poly(ethylene glycol)-methylamino (mPEG-NHMe) is a monofunctional precision PEG derivative with a defined chain length. One end bears a methoxy group. The other end bears a methylamino group. Discrete chain lengths with different degrees of polymerization are available. The secondary amine can participate in suitable acylation or other amine reactions, enabling comparisons of amine substitution and conjugation routes. Capping one end defines the direction of derivatization, enabling the hydrophilic PEG segment to be attached to a target molecule and functional linkers of the required length to be constructed. Applications: Secondary-amine PEG derivatization; N-substituted linker synthesis; Amine-terminus structure comparisons. Customization available.

n = 4–192 · 30 Catalog Nos.View Series →

mPEG-NMe2

Methoxy-poly(ethylene glycol)-dimethylamino (mPEG-NMe2) is a monofunctional precision PEG derivative with a defined chain length. One end bears a methoxy group. The other end bears a dimethylamino group. Discrete chain lengths with different degrees of polymerization are available. The tertiary amine provides sites for acid–base and ionic interactions, enabling studies of terminal charge presentation in different media. Capping one end defines the direction of derivatization, enabling the hydrophilic PEG segment to be attached to a target molecule and functional linkers of the required length to be constructed. Applications: Tertiary-amine-terminated functional materials; Acid–base response studies; Interfacial charge adjustment. Customization available.

n = 4–192 · 30 Catalog Nos.View Series →

mPEG-Biotin

Methoxy-poly(ethylene glycol)-biotin (mPEG-Biotin) is a monofunctional precision PEG derivative with a defined chain length. One end bears a methoxy group. The other end bears a biotin group. Discrete chain lengths with different degrees of polymerization are available. Biotin can bind avidin or streptavidin. The PEG spacer separates the recognition unit from the immobilization surface. Capping one end defines the direction of derivatization, enabling the hydrophilic PEG segment to be attached to a target molecule and functional linkers of the required length to be constructed. Applications: Affinity capture; Biotin-probe assembly; Surface presentation of recognition units. Customization available.

n = 4–192 · 30 Catalog Nos.View Series →

mPEG-Folate

Methoxy-poly(ethylene glycol)-folic acid (mPEG-Folate) is a monofunctional precision PEG derivative with a defined chain length. One end bears a methoxy group. The other end bears a folate group. Discrete chain lengths with different degrees of polymerization are available. The folate terminus supports ligand presentation and receptor-related binding studies, allowing ligand position and PEG chain length to be varied independently. Capping one end defines the direction of derivatization, enabling the hydrophilic PEG segment to be attached to a target molecule and functional linkers of the required length to be constructed. Applications: Folate ligand presentation; Receptor-binding studies; Ligand-modified carrier construction. Customization available.

n = 4–192 · 30 Catalog Nos.View Series →

mPEG-DBCO

Methoxy-poly(ethylene glycol)-dibenzocyclooctyne (mPEG-DBCO) is a monofunctional precision PEG derivative with a defined chain length. One end bears a methoxy group. The other end bears a dibenzocyclooctyne (DBCO) group. Discrete chain lengths with different degrees of polymerization are available. The strained DBCO alkyne can undergo copper-free click reactions with azides, enabling attachment to molecules or materials with preinstalled azide sites. Capping one end defines the direction of derivatization, enabling the hydrophilic PEG segment to be attached to a target molecule and functional linkers of the required length to be constructed. Applications: Copper-free click chemistry; Azide-bearing biomolecule labeling; Bioorthogonal linkers. Customization available.

n = 4–192 · 30 Catalog Nos.View Series →

mPEG-BCN

Methoxy-poly(ethylene glycol)-bicyclononyne (mPEG-BCN) is a monofunctional precision PEG derivative with a defined chain length. One end bears a methoxy group. The other end bears a bicyclononyne (BCN) group. Discrete chain lengths with different degrees of polymerization are available. BCN is a strained alkyne that can undergo copper-free cycloaddition with azides, allowing comparisons of different strained-alkyne conjugation termini. Capping one end defines the direction of derivatization, enabling the hydrophilic PEG segment to be attached to a target molecule and functional linkers of the required length to be constructed. Applications: Strain-promoted click conjugation; Azide-probe conjugation; Strained-alkyne end-group structure studies. Customization available.

n = 4–192 · 30 Catalog Nos.View Series →

mPEG-TCO

Methoxy-poly(ethylene glycol)-trans-cyclooctene (mPEG-TCO) is a monofunctional precision PEG derivative with a defined chain length. One end bears a methoxy group. The other end bears a trans-cyclooctene (TCO) group. Discrete chain lengths with different degrees of polymerization are available. Trans-cyclooctene can pair with tetrazines in inverse-electron-demand Diels–Alder reactions for assembly of bioorthogonal modules. Capping one end defines the direction of derivatization, enabling the hydrophilic PEG segment to be attached to a target molecule and functional linkers of the required length to be constructed. Applications: Tetrazine-paired bioorthogonal ligation; Rapid probe assembly studies; TCO linker synthesis. Customization available.

n = 4–192 · 30 Catalog Nos.View Series →

mPEG-SPDP

Methoxy-poly(ethylene glycol)-pyridyl disulfide (mPEG-SPDP) is a monofunctional precision PEG derivative with a defined chain length. One end bears a methoxy group. The other end bears a pyridyl disulfide group. Discrete chain lengths with different degrees of polymerization are available. The pyridyl disulfide can exchange with thiols to form disulfide linkages, providing reducible molecular connection sites. Capping one end defines the direction of derivatization, enabling the hydrophilic PEG segment to be attached to a target molecule and functional linkers of the required length to be constructed. Applications: Thiol-exchange conjugation; Reducible linkers; Protein–carrier crosslinking. Customization available.

n = 4–192 · 30 Catalog Nos.View Series →

Cyclic PEG with PEG arm, Hydroxyl

cPEG-PEG-OH

Hydroxyl-terminated PEG arm on a cyclic poly(ethylene glycol) scaffold (cPEG-PEG-OH) is a cyclic-topology derivative bearing a pendant PEG arm. The specified conjugation or functional groups are located on the pendant segment. Discrete chain lengths with different degrees of polymerization are available. The terminal hydroxyl group can be further modified by esterification, etherification, or other functional-group transformations. The cyclic scaffold retains its topological features, while the pendant arm provides conjugation and presentation functions. This allows the effects of ring structure and pendant-chain length on molecular conjugation to be distinguished. Applications: Cyclic topology effect studies; Molecular conjugation through pendant arms; Precision PEG derivatization; Bioconjugation linker synthesis. Customization available.

n = 4–96 · 28 Catalog Nos.View Series →

Cyclic PEG with PEG arm, Amine

cPEG-PEG-NH2

Primary amine-terminated PEG arm on a cyclic poly(ethylene glycol) scaffold (cPEG-PEG-NH2) is a cyclic-topology derivative bearing a pendant PEG arm. The specified conjugation or functional groups are located on the pendant segment. Discrete chain lengths with different degrees of polymerization are available. The primary amine can react with activated carboxyl groups or NHS esters to form amide bonds and introduce carboxyl-containing functional moieties. The cyclic scaffold retains its topological features, while the pendant arm provides conjugation and presentation functions. This allows the effects of ring structure and pendant-chain length on molecular conjugation to be distinguished. Applications: Cyclic topology effect studies; Molecular conjugation through pendant arms; Amide-based bioconjugation; Peptide and functional small-molecule conjugation. Customization available.

n = 4–96 · 28 Catalog Nos.View Series →

cPEG-PEG-CH2COONHS Ester

N-hydroxysuccinimide ester-terminated PEG arm on a cyclic poly(ethylene glycol) scaffold (cPEG-PEG-NHS) is a cyclic-topology derivative bearing a pendant PEG arm. The specified conjugation or functional groups are located on the pendant segment. Discrete chain lengths with different degrees of polymerization are available. The NHS ester can form amide bonds with primary amines, enabling conjugation to amine-containing small molecules, peptides, proteins, or material surfaces. The cyclic scaffold retains its topological features, while the pendant arm provides conjugation and presentation functions. This allows the effects of ring structure and pendant-chain length on molecular conjugation to be distinguished. Applications: Cyclic topology effect studies; Molecular conjugation through pendant arms; Amine modification in proteins and peptides; Amine-functionalized surface conjugation. Customization available.

n = 4–96 · 28 Catalog Nos.View Series →

Cyclic PEG with PEG arm, Thiol

cPEG-PEG-SH

Thiol-terminated PEG arm on a cyclic poly(ethylene glycol) scaffold (cPEG-PEG-SH) is a cyclic-topology derivative bearing a pendant PEG arm. The specified conjugation or functional groups are located on the pendant segment. Discrete chain lengths with different degrees of polymerization are available. The thiol can add to maleimides or participate in disulfide formation, offering different molecular conjugation routes. The cyclic scaffold retains its topological features, while the pendant arm provides conjugation and presentation functions. This allows the effects of ring structure and pendant-chain length on molecular conjugation to be distinguished. Applications: Cyclic topology effect studies; Molecular conjugation through pendant arms; Thiol-selective conjugation; Disulfide-linkage design. Customization available.

n = 4–96 · 28 Catalog Nos.View Series →

Cyclic PEG with PEG arm, Azide

cPEG-PEG-N3

Azido-terminated PEG arm on a cyclic poly(ethylene glycol) scaffold (cPEG-PEG-N3) is a cyclic-topology derivative bearing a pendant PEG arm. The specified conjugation or functional groups are located on the pendant segment. Discrete chain lengths with different degrees of polymerization are available. The azide can undergo copper-catalyzed click reactions with terminal alkynes or copper-free click conjugation with strained alkynes such as DBCO and BCN. The cyclic scaffold retains its topological features, while the pendant arm provides conjugation and presentation functions. This allows the effects of ring structure and pendant-chain length on molecular conjugation to be distinguished. Applications: Cyclic topology effect studies; Molecular conjugation through pendant arms; Azide click chemistry; Bioorthogonal conjugation. Customization available.

n = 4–96 · 28 Catalog Nos.View Series →

Cyclic PEG with PEG arm, Alkyne

cPEG-PEG-Alkyne

Terminal alkyne-terminated PEG arm on a cyclic poly(ethylene glycol) scaffold (cPEG-PEG-Alkyne) is a cyclic-topology derivative bearing a pendant PEG arm. The specified conjugation or functional groups are located on the pendant segment. Discrete chain lengths with different degrees of polymerization are available. The terminal alkyne can undergo suitable copper-catalyzed cycloaddition with azides, linking the PEG spacer to target molecular modules. The cyclic scaffold retains its topological features, while the pendant arm provides conjugation and presentation functions. This allows the effects of ring structure and pendant-chain length on molecular conjugation to be distinguished. Applications: Cyclic topology effect studies; Molecular conjugation through pendant arms; Copper-catalyzed azide–alkyne click chemistry; Probe and ligand assembly. Customization available.

n = 4–96 · 28 Catalog Nos.View Series →

Cyclic PEG with PEG arm, Mal

cPEG-PEG-Mal

Maleimide-terminated PEG arm on a cyclic poly(ethylene glycol) scaffold (cPEG-PEG-MAL) is a cyclic-topology derivative bearing a pendant PEG arm. The specified conjugation or functional groups are located on the pendant segment. Discrete chain lengths with different degrees of polymerization are available. The maleimide can add to cysteine thiols or other thiolated modules, providing a handle for conjugation at thiol sites. The cyclic scaffold retains its topological features, while the pendant arm provides conjugation and presentation functions. This allows the effects of ring structure and pendant-chain length on molecular conjugation to be distinguished. Applications: Cyclic topology effect studies; Molecular conjugation through pendant arms; Cysteine-site modification; Thiol-selective bioconjugation. Customization available.

n = 4–96 · 28 Catalog Nos.View Series →

Methoxy-poly(ethylene glycol) succinimidyl carbonate (mPEG-DSC; mPEG-SC)

mPEG-DSC; Methoxy-PEG succinimidyl carbonate

Methoxy-poly(ethylene glycol) succinimidyl carbonate; mPEG-DSC; also known as mPEG-SC is a family of monofunctional precision PEG derivatives with defined chain lengths. One end bears a methoxy group. The other end bears an N-succinimidyl activated carbonate group. The reactive terminus is PEG-O-C(=O)-O-NHS. It undergoes nucleophilic substitution with primary amines, releasing N-hydroxysuccinimide and forming a carbamate linkage. The methoxy cap defines the principal conjugation direction. A defined PEG chain length enables comparisons of spacer length and site accessibility while keeping the terminal reaction chemistry unchanged. It is suitable for PEGylation and linker construction involving amine-containing small molecules, peptides, proteins, and amine-functionalized material surfaces. Applications: Carbamate-based bioconjugation; Protein and peptide PEGylation; Amine-functionalized surface modification; Precision PEG linker synthesis. Customization available.

n = 4–192 · 30 Catalog Nos.View Series →

Cyclic PEG with PEG arm, Carboxyl

cPEG-PEG-CH2COOH

Carboxylic acid-terminated PEG arm on a cyclic poly(ethylene glycol) scaffold (cPEG-PEG-COOH) is a cyclic-topology derivative bearing a pendant PEG arm. The specified conjugation or functional groups are located on the pendant segment. Discrete chain lengths with different degrees of polymerization are available. The carboxyl group can be activated for amide coupling with primary-amine-containing molecules, retaining a handle for subsequent ligand or carrier attachment. The cyclic scaffold retains its topological features, while the pendant arm provides conjugation and presentation functions. This allows the effects of ring structure and pendant-chain length on molecular conjugation to be distinguished. Applications: Cyclic topology effect studies; Molecular conjugation through pendant arms; Amine-containing molecule conjugation; Drug and ligand modification. Customization available.

n = 4–96 · 28 Catalog Nos.View Series →

mPEG-Hydrazide

n = 2–48 · 26 Catalog Nos.View Series →