mPEG-TCO

Methoxy-poly(ethylene glycol)-trans-cyclooctene (mPEG-TCO) is a monofunctional precision PEG derivative with a defined chain length. One end bears a methoxy group. The other end bears a trans-cyclooctene (TCO) group. Discrete chain lengths with different degrees of polymerization are available. Trans-cyclooctene can pair with tetrazines in inverse-electron-demand Diels–Alder reactions for assembly of bioorthogonal modules. Capping one end defines the direction of derivatization, enabling the hydrophilic PEG segment to be attached to a target molecule and functional linkers of the required length to be constructed.

Customization available.