N3-PEG-OH

Alpha-(azido)-omega-(hydroxy) poly(ethylene glycol) (N3-PEG-OH) is a heterobifunctional precision PEG derivative with a defined chain length. The two ends bear azide and hydroxyl groups, respectively. Discrete chain lengths with different degrees of polymerization are available. The azide can undergo copper-catalyzed click reactions with terminal alkynes or copper-free click conjugation with strained alkynes such as DBCO and BCN. The terminal hydroxyl group can be further modified by esterification, etherification, or other functional-group transformations. The two end groups can be coupled sequentially using compatible reactions and appropriate protection strategies, enabling surface immobilization, functional-molecule bridging, and directional spacer synthesis.

Customization available.