mPEG-DSC; Methoxy-PEG succinimidyl carbonate

Also known as: Methoxy-poly(ethylene glycol) succinimidyl carbonate;

mPEG-DSC; also known as mPEG-SC is a family of monofunctional precision PEG derivatives with defined chain lengths. One end bears a methoxy group. The other end bears an N-succinimidyl activated carbonate group. The reactive terminus is PEG-O-C(=O)-O-NHS. It undergoes nucleophilic substitution with primary amines, releasing N-hydroxysuccinimide and forming a carbamate linkage. The methoxy cap defines the principal conjugation direction. A defined PEG chain length enables comparisons of spacer length and site accessibility while keeping the terminal reaction chemistry unchanged. It is suitable for PEGylation and linker construction involving amine-containing small molecules, peptides, proteins, and amine-functionalized material surfaces.

Customization available.