mPEG-CH2COOtBu

Methoxy-poly(ethylene glycol)-tert-butyl-protected carboxymethyl (mPEG-CH2COOtBu) is a monofunctional precision PEG derivative with a defined chain length. One end bears a methoxy group. The other end bears a tert-butyl-ester-protected carboxymethyl group. Discrete chain lengths with different degrees of polymerization are available. The tert-butyl ester temporarily protects a carboxyl precursor. Appropriate acidic deprotection enables subsequent carboxyl activation and amide coupling. Capping one end defines the direction of derivatization, enabling the hydrophilic PEG segment to be attached to a target molecule and functional linkers of the required length to be constructed.

Customization available.