cPEG-PEG-CH2COOH

Carboxylic acid-terminated PEG arm on a cyclic poly(ethylene glycol) scaffold (cPEG-PEG-COOH) is a cyclic-topology derivative bearing a pendant PEG arm. The specified conjugation or functional groups are located on the pendant segment. Discrete chain lengths with different degrees of polymerization are available. The carboxyl group can be activated for amide coupling with primary-amine-containing molecules, retaining a handle for subsequent ligand or carrier attachment. The cyclic scaffold retains its topological features, while the pendant arm provides conjugation and presentation functions. This allows the effects of ring structure and pendant-chain length on molecular conjugation to be distinguished.

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