H2N-PEG-SS-COOH

Primary amine-functionalized discrete poly(ethylene glycol)-disulfide-carboxylic acid (H2N-PEG-SS-COOH) is an ADC linker intermediate containing a defined-length PEG spacer. It contains a primary amine reactive terminus and a disulfide linkage. Discrete chain lengths with different degrees of polymerization are available. The primary amine can react with activated carboxyl groups or NHS esters to form amide bonds and introduce carboxyl-containing functional moieties. The disulfide can act as a reduction-responsive linking unit. After activation, the carboxyl group can be used to attach amine-containing payloads or other modules.

Customization available.