BCN-PEG-GGFG-COOH

Bicyclononyne-functionalized discrete poly(ethylene glycol)-glycyl-glycyl-phenylalanyl-glycine-carboxylic acid (BCN-PEG-GGFG-COOH) is an ADC linker intermediate containing a defined-length PEG spacer. It contains a bicyclononyne (BCN) reactive terminus and a glycine–glycine–phenylalanine–glycine tetrapeptide. Discrete chain lengths with different degrees of polymerization are available. BCN is a strained alkyne that can undergo copper-free cycloaddition with azides, allowing comparisons of different strained-alkyne conjugation termini. The glycine–glycine–phenylalanine–glycine tetrapeptide provides a sequence variable for studies of protease-cleavable linkers. The terminal carboxyl group can be activated for coupling with amine-containing modules.

Customization available.