BocNH-PEG-SS-COOH

tert-butoxycarbonyl-protected amino-functionalized discrete poly(ethylene glycol)-disulfide-carboxylic acid (BocNH-PEG-SS-COOH) is an ADC linker intermediate containing a defined-length PEG spacer. It contains a Boc-protected amine reactive terminus and a disulfide linkage. Discrete chain lengths with different degrees of polymerization are available. Boc protection separates amine reactions from other synthetic steps. Appropriate deprotection exposes a primary amine for subsequent conjugation. The disulfide can act as a reduction-responsive linking unit. After activation, the carboxyl group can be used to attach amine-containing payloads or other modules.

Customization available.