H2N-PEG-Val-Ala-PAB-OH

Primary amine-functionalized discrete poly(ethylene glycol)-valyl-alanine-p-aminobenzyl alcohol (H2N-PEG-Val-Ala-PAB-OH) is an ADC linker intermediate containing a defined-length PEG spacer. It contains a primary amine reactive terminus and a valine–alanine dipeptide. Discrete chain lengths with different degrees of polymerization are available. The primary amine can react with activated carboxyl groups or NHS esters to form amide bonds and introduce carboxyl-containing functional moieties. The valine–alanine dipeptide provides a sequence variable for studies of protease-cleavable linkers. The PAB spacer links peptide cleavage to the subsequent self-immolation process. The PAB hydroxyl group retains a synthetic handle for subsequent activation and payload derivatization.

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