BCN-PEG-GFLG-COOH

Bicyclononyne-functionalized discrete poly(ethylene glycol)-glycyl-phenylalanyl-leucyl-glycine-carboxylic acid (BCN-PEG-GFLG-COOH) is an ADC linker intermediate containing a defined-length PEG spacer. It contains a bicyclononyne (BCN) reactive terminus and a glycine–phenylalanine–leucine–glycine tetrapeptide. Discrete chain lengths with different degrees of polymerization are available. BCN is a strained alkyne that can undergo copper-free cycloaddition with azides, allowing comparisons of different strained-alkyne conjugation termini. The glycine–phenylalanine–leucine–glycine tetrapeptide provides a sequence variable for studies of protease-cleavable linkers. The terminal carboxyl group can be activated for coupling with amine-containing modules.

Customization available.