BocNH-PEG-GGFG-COOH

tert-butoxycarbonyl-protected amino-functionalized discrete poly(ethylene glycol)-glycyl-glycyl-phenylalanyl-glycine-carboxylic acid (BocNH-PEG-GGFG-COOH) is an ADC linker intermediate containing a defined-length PEG spacer. It contains a Boc-protected amine reactive terminus and a glycine–glycine–phenylalanine–glycine tetrapeptide. Discrete chain lengths with different degrees of polymerization are available. Boc protection separates amine reactions from other synthetic steps. Appropriate deprotection exposes a primary amine for subsequent conjugation. The glycine–glycine–phenylalanine–glycine tetrapeptide provides a sequence variable for studies of protease-cleavable linkers. The terminal carboxyl group can be activated for coupling with amine-containing modules.

Customization available.