H2N-PEG-GGFG-COOH

Primary amine-functionalized discrete poly(ethylene glycol)-glycyl-glycyl-phenylalanyl-glycine-carboxylic acid (H2N-PEG-GGFG-COOH) is an ADC linker intermediate containing a defined-length PEG spacer. It contains a primary amine reactive terminus and a glycine–glycine–phenylalanine–glycine tetrapeptide. Discrete chain lengths with different degrees of polymerization are available. The primary amine can react with activated carboxyl groups or NHS esters to form amide bonds and introduce carboxyl-containing functional moieties. The glycine–glycine–phenylalanine–glycine tetrapeptide provides a sequence variable for studies of protease-cleavable linkers. The terminal carboxyl group can be activated for coupling with amine-containing modules.

Customization available.