BCN-PEG-SS-COOH

Bicyclononyne-functionalized discrete poly(ethylene glycol)-disulfide-carboxylic acid (BCN-PEG-SS-COOH) is an ADC linker intermediate containing a defined-length PEG spacer. It contains a bicyclononyne (BCN) reactive terminus and a disulfide linkage. Discrete chain lengths with different degrees of polymerization are available. BCN is a strained alkyne that can undergo copper-free cycloaddition with azides, allowing comparisons of different strained-alkyne conjugation termini. The disulfide can act as a reduction-responsive linking unit. After activation, the carboxyl group can be used to attach amine-containing payloads or other modules.

Customization available.