DBCO-PEG-SS-COOH

Dibenzocyclooctyne-functionalized discrete poly(ethylene glycol)-disulfide-carboxylic acid (DBCO-PEG-SS-COOH) is an ADC linker intermediate containing a defined-length PEG spacer. It contains a dibenzocyclooctyne (DBCO) reactive terminus and a disulfide linkage. Discrete chain lengths with different degrees of polymerization are available. The strained DBCO alkyne can undergo copper-free click reactions with azides, enabling attachment to molecules or materials with preinstalled azide sites. The disulfide can act as a reduction-responsive linking unit. After activation, the carboxyl group can be used to attach amine-containing payloads or other modules.

Customization available.