Mal-PEG-Hydrazide

Maleimide-functionalized discrete poly(ethylene glycol)-hydrazide (MAL-PEG-Hydrazide) is an ADC linker intermediate containing a defined-length PEG spacer. It contains a maleimide reactive terminus and a hydrazide group. Discrete chain lengths with different degrees of polymerization are available. The maleimide can add to cysteine thiols or other thiolated modules, providing a handle for conjugation at thiol sites. The hydrazide at the other end can form hydrazone linkages with aldehydes or ketones, allowing carbonyl capture and reactions at the other terminus to be performed sequentially.

Customization available.