Alkyne-PEG-GFLG-COOH

Terminal alkyne-functionalized discrete poly(ethylene glycol)-glycyl-phenylalanyl-leucyl-glycine-carboxylic acid (Alkyne-PEG-GFLG-COOH) is an ADC linker intermediate containing a defined-length PEG spacer. It contains a terminal alkyne reactive terminus and a glycine–phenylalanine–leucine–glycine tetrapeptide. Discrete chain lengths with different degrees of polymerization are available. The terminal alkyne can undergo suitable copper-catalyzed cycloaddition with azides, linking the PEG spacer to target molecular modules. The glycine–phenylalanine–leucine–glycine tetrapeptide provides a sequence variable for studies of protease-cleavable linkers. The terminal carboxyl group can be activated for coupling with amine-containing modules.

Customization available.