N3-PEG-Val-Ala-PAB-PNP

Azido-functionalized discrete poly(ethylene glycol)-valyl-alanine-p-aminobenzyl p-nitrophenyl carbonate (N3-PEG-Val-Ala-PAB-PNP) is an ADC linker intermediate containing a defined-length PEG spacer. It contains an azide reactive terminus and a valine–alanine dipeptide. Discrete chain lengths with different degrees of polymerization are available. The azide can undergo copper-catalyzed click reactions with terminal alkynes or copper-free click conjugation with strained alkynes such as DBCO and BCN. The valine–alanine dipeptide provides a sequence variable for studies of protease-cleavable linkers. The PAB spacer links peptide cleavage to the subsequent self-immolation process. The PNP-activated terminus can be further coupled to suitable amine-containing payloads.

Customization available.