BocNH-PEG-Hydrazide

tert-butoxycarbonyl-protected amino-functionalized discrete poly(ethylene glycol)-hydrazide (BocNH-PEG-Hydrazide) is an ADC linker intermediate containing a defined-length PEG spacer. It contains a Boc-protected amine reactive terminus and a hydrazide group. Discrete chain lengths with different degrees of polymerization are available. Boc protection separates amine reactions from other synthetic steps. Appropriate deprotection exposes a primary amine for subsequent conjugation. The hydrazide at the other end can form hydrazone linkages with aldehydes or ketones, allowing carbonyl capture and reactions at the other terminus to be performed sequentially.

Customization available.