BocNH-PEG-GFLG-COOH

tert-butoxycarbonyl-protected amino-functionalized discrete poly(ethylene glycol)-glycyl-phenylalanyl-leucyl-glycine-carboxylic acid (BocNH-PEG-GFLG-COOH) is an ADC linker intermediate containing a defined-length PEG spacer. It contains a Boc-protected amine reactive terminus and a glycine–phenylalanine–leucine–glycine tetrapeptide. Discrete chain lengths with different degrees of polymerization are available. Boc protection separates amine reactions from other synthetic steps. Appropriate deprotection exposes a primary amine for subsequent conjugation. The glycine–phenylalanine–leucine–glycine tetrapeptide provides a sequence variable for studies of protease-cleavable linkers. The terminal carboxyl group can be activated for coupling with amine-containing modules.

Customization available.