DBCO-PEG-Hydrazide

Dibenzocyclooctyne-functionalized discrete poly(ethylene glycol)-hydrazide (DBCO-PEG-Hydrazide) is an ADC linker intermediate containing a defined-length PEG spacer. It contains a dibenzocyclooctyne (DBCO) reactive terminus and a hydrazide group. Discrete chain lengths with different degrees of polymerization are available. The strained DBCO alkyne can undergo copper-free click reactions with azides, enabling attachment to molecules or materials with preinstalled azide sites. The hydrazide at the other end can form hydrazone linkages with aldehydes or ketones, allowing carbonyl capture and reactions at the other terminus to be performed sequentially.

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