DBCO-PEG-GGFG-COOH

Dibenzocyclooctyne-functionalized discrete poly(ethylene glycol)-glycyl-glycyl-phenylalanyl-glycine-carboxylic acid (DBCO-PEG-GGFG-COOH) is an ADC linker intermediate containing a defined-length PEG spacer. It contains a dibenzocyclooctyne (DBCO) reactive terminus and a glycine–glycine–phenylalanine–glycine tetrapeptide. Discrete chain lengths with different degrees of polymerization are available. The strained DBCO alkyne can undergo copper-free click reactions with azides, enabling attachment to molecules or materials with preinstalled azide sites. The glycine–glycine–phenylalanine–glycine tetrapeptide provides a sequence variable for studies of protease-cleavable linkers. The terminal carboxyl group can be activated for coupling with amine-containing modules.

Customization available.