H2N-PEG-Hydrazide

Primary amine-functionalized discrete poly(ethylene glycol)-hydrazide (H2N-PEG-Hydrazide) is an ADC linker intermediate containing a defined-length PEG spacer. It contains a primary amine reactive terminus and a hydrazide group. Discrete chain lengths with different degrees of polymerization are available. The primary amine can react with activated carboxyl groups or NHS esters to form amide bonds and introduce carboxyl-containing functional moieties. The hydrazide at the other end can form hydrazone linkages with aldehydes or ketones, allowing carbonyl capture and reactions at the other terminus to be performed sequentially.

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