N3-PEG-SS-COOH

Azido-functionalized discrete poly(ethylene glycol)-disulfide-carboxylic acid (N3-PEG-SS-COOH) is an ADC linker intermediate containing a defined-length PEG spacer. It contains an azide reactive terminus and a disulfide linkage. Discrete chain lengths with different degrees of polymerization are available. The azide can undergo copper-catalyzed click reactions with terminal alkynes or copper-free click conjugation with strained alkynes such as DBCO and BCN. The disulfide can act as a reduction-responsive linking unit. After activation, the carboxyl group can be used to attach amine-containing payloads or other modules.

Customization available.