TCO-PEG-SS-COOH

Trans-cyclooctene-functionalized discrete poly(ethylene glycol)-disulfide-carboxylic acid (TCO-PEG-SS-COOH) is an ADC linker intermediate containing a defined-length PEG spacer. It contains a trans-cyclooctene (TCO) reactive terminus and a disulfide linkage. Discrete chain lengths with different degrees of polymerization are available. Trans-cyclooctene can pair with tetrazines in inverse-electron-demand Diels–Alder reactions for assembly of bioorthogonal modules. The disulfide can act as a reduction-responsive linking unit. After activation, the carboxyl group can be used to attach amine-containing payloads or other modules.

Customization available.