BCN-PEG-Hydrazide

Bicyclononyne-functionalized discrete poly(ethylene glycol)-hydrazide (BCN-PEG-Hydrazide) is an ADC linker intermediate containing a defined-length PEG spacer. It contains a bicyclononyne (BCN) reactive terminus and a hydrazide group. Discrete chain lengths with different degrees of polymerization are available. BCN is a strained alkyne that can undergo copper-free cycloaddition with azides, allowing comparisons of different strained-alkyne conjugation termini. The hydrazide at the other end can form hydrazone linkages with aldehydes or ketones, allowing carbonyl capture and reactions at the other terminus to be performed sequentially.

Customization available.