TCO-PEG-Hydrazide

Trans-cyclooctene-functionalized discrete poly(ethylene glycol)-hydrazide (TCO-PEG-Hydrazide) is an ADC linker intermediate containing a defined-length PEG spacer. It contains a trans-cyclooctene (TCO) reactive terminus and a hydrazide group. Discrete chain lengths with different degrees of polymerization are available. Trans-cyclooctene can pair with tetrazines in inverse-electron-demand Diels–Alder reactions for assembly of bioorthogonal modules. The hydrazide at the other end can form hydrazone linkages with aldehydes or ketones, allowing carbonyl capture and reactions at the other terminus to be performed sequentially.

Customization available.