Mal-PEG-SS-COOH

Maleimide-functionalized discrete poly(ethylene glycol)-disulfide-carboxylic acid (MAL-PEG-SS-COOH) is an ADC linker intermediate containing a defined-length PEG spacer. It contains a maleimide reactive terminus and a disulfide linkage. Discrete chain lengths with different degrees of polymerization are available. The maleimide can add to cysteine thiols or other thiolated modules, providing a handle for conjugation at thiol sites. The disulfide can act as a reduction-responsive linking unit. After activation, the carboxyl group can be used to attach amine-containing payloads or other modules.

Customization available.