Alkyne-PEG-Hydrazide

Terminal alkyne-functionalized discrete poly(ethylene glycol)-hydrazide (Alkyne-PEG-Hydrazide) is an ADC linker intermediate containing a defined-length PEG spacer. It contains a terminal alkyne reactive terminus and a hydrazide group. Discrete chain lengths with different degrees of polymerization are available. The terminal alkyne can undergo suitable copper-catalyzed cycloaddition with azides, linking the PEG spacer to target molecular modules. The hydrazide at the other end can form hydrazone linkages with aldehydes or ketones, allowing carbonyl capture and reactions at the other terminus to be performed sequentially.

Customization available.