Alkyne-PEG-SS-COOH

Terminal alkyne-functionalized discrete poly(ethylene glycol)-disulfide-carboxylic acid (Alkyne-PEG-SS-COOH) is an ADC linker intermediate containing a defined-length PEG spacer. It contains a terminal alkyne reactive terminus and a disulfide linkage. Discrete chain lengths with different degrees of polymerization are available. The terminal alkyne can undergo suitable copper-catalyzed cycloaddition with azides, linking the PEG spacer to target molecular modules. The disulfide can act as a reduction-responsive linking unit. After activation, the carboxyl group can be used to attach amine-containing payloads or other modules.

Customization available.