DBCO-PEG-CH2CH2COOH

Alpha-(dibenzocyclooctyne)-omega-(carboxy) poly(ethylene glycol) (DBCO-PEG-COOH) is a heterobifunctional precision PEG derivative with a defined chain length. The two ends bear dibenzocyclooctyne (DBCO) and carboxyl groups, respectively. Discrete chain lengths with different degrees of polymerization are available. The strained DBCO alkyne can undergo copper-free click reactions with azides, enabling attachment to molecules or materials with preinstalled azide sites. The carboxyl group can be activated for amide coupling with primary-amine-containing molecules, retaining a handle for subsequent ligand or carrier attachment. The two end groups can be coupled sequentially using compatible reactions and appropriate protection strategies, enabling surface immobilization, functional-molecule bridging, and directional spacer synthesis.

Customization available.