BCN-PEG-OH

Alpha-(bicyclononyne)-omega-(hydroxy) poly(ethylene glycol) (BCN-PEG-OH) is a heterobifunctional precision PEG derivative with a defined chain length. The two ends bear bicyclononyne (BCN) and hydroxyl groups, respectively. Discrete chain lengths with different degrees of polymerization are available. BCN is a strained alkyne that can undergo copper-free cycloaddition with azides, allowing comparisons of different strained-alkyne conjugation termini. The terminal hydroxyl group can be further modified by esterification, etherification, or other functional-group transformations. The two end groups can be coupled sequentially using compatible reactions and appropriate protection strategies, enabling surface immobilization, functional-molecule bridging, and directional spacer synthesis.

Customization available.