TCO-PEG-OH

Alpha-(trans-cyclooctene)-omega-(hydroxy) poly(ethylene glycol) (TCO-PEG-OH) is a heterobifunctional precision PEG derivative with a defined chain length. The two ends bear trans-cyclooctene (TCO) and hydroxyl groups, respectively. Discrete chain lengths with different degrees of polymerization are available. Trans-cyclooctene can pair with tetrazines in inverse-electron-demand Diels–Alder reactions for assembly of bioorthogonal modules. The terminal hydroxyl group can be further modified by esterification, etherification, or other functional-group transformations. The two end groups can be coupled sequentially using compatible reactions and appropriate protection strategies, enabling surface immobilization, functional-molecule bridging, and directional spacer synthesis.

Customization available.