BCN-PEG-Mal

Alpha-(bicyclononyne)-omega-(maleimide) poly(ethylene glycol) (BCN-PEG-MAL) is a heterobifunctional precision PEG derivative with a defined chain length. The two ends bear bicyclononyne (BCN) and maleimide groups, respectively. Discrete chain lengths with different degrees of polymerization are available. BCN is a strained alkyne that can undergo copper-free cycloaddition with azides, allowing comparisons of different strained-alkyne conjugation termini. The maleimide can add to cysteine thiols or other thiolated modules, providing a handle for conjugation at thiol sites. The two end groups can be coupled sequentially using compatible reactions and appropriate protection strategies, enabling surface immobilization, functional-molecule bridging, and directional spacer synthesis.

Customization available.