Alkyne-PEG-Mal

Alpha-(terminal alkyne)-omega-(maleimide) poly(ethylene glycol) (Alkyne-PEG-MAL) is a heterobifunctional precision PEG derivative with a defined chain length. The two ends bear terminal alkyne and maleimide groups, respectively. Discrete chain lengths with different degrees of polymerization are available. The terminal alkyne can undergo suitable copper-catalyzed cycloaddition with azides, linking the PEG spacer to target molecular modules. The maleimide can add to cysteine thiols or other thiolated modules, providing a handle for conjugation at thiol sites. The two end groups can be coupled sequentially using compatible reactions and appropriate protection strategies, enabling surface immobilization, functional-molecule bridging, and directional spacer synthesis.

Customization available.