BCN-PEG-CH2CH2COONHS Ester

Alpha-(bicyclononyne)-omega-(N-hydroxysuccinimide ester) poly(ethylene glycol) (BCN-PEG-NHS) is a heterobifunctional precision PEG derivative with a defined chain length. The two ends bear bicyclononyne (BCN) and N-hydroxysuccinimide ester groups, respectively. Discrete chain lengths with different degrees of polymerization are available. BCN is a strained alkyne that can undergo copper-free cycloaddition with azides, allowing comparisons of different strained-alkyne conjugation termini. The NHS ester can form amide bonds with primary amines, enabling conjugation to amine-containing small molecules, peptides, proteins, or material surfaces. The two end groups can be coupled sequentially using compatible reactions and appropriate protection strategies, enabling surface immobilization, functional-molecule bridging, and directional spacer synthesis.

Customization available.