H2N-PEG-CH2CH2COOH

Alpha-(amino)-omega-(carboxy) poly(ethylene glycol) (H2N-PEG-COOH) is a heterobifunctional precision PEG derivative with a defined chain length. The two ends bear primary amine and carboxyl groups, respectively. Discrete chain lengths with different degrees of polymerization are available. The primary amine can react with activated carboxyl groups or NHS esters to form amide bonds and introduce carboxyl-containing functional moieties. The carboxyl group can be activated for amide coupling with primary-amine-containing molecules, retaining a handle for subsequent ligand or carrier attachment. The two end groups can be coupled sequentially using compatible reactions and appropriate protection strategies, enabling surface immobilization, functional-molecule bridging, and directional spacer synthesis.

Customization available.