HO-PEG-NHBoc

Alpha-(hydroxy)-omega-(tert-butoxycarbonyl-protected amino) poly(ethylene glycol) (HO-PEG-BocNH) is a heterobifunctional precision PEG derivative with a defined chain length. The two ends bear hydroxyl and Boc-protected amine groups, respectively. Discrete chain lengths with different degrees of polymerization are available. The terminal hydroxyl group can be further modified by esterification, etherification, or other functional-group transformations. Boc protection separates amine reactions from other synthetic steps. Appropriate deprotection exposes a primary amine for subsequent conjugation. The two end groups can be coupled sequentially using compatible reactions and appropriate protection strategies, enabling surface immobilization, functional-molecule bridging, and directional spacer synthesis.

Customization available.