HO-PEG-ONH2

Alpha-(hydroxy)-omega-(aminooxy) poly(ethylene glycol) (HO-PEG-ONH2) is a heterobifunctional precision PEG derivative with a defined chain length. The two ends bear hydroxyl and aminooxy groups, respectively. Discrete chain lengths with different degrees of polymerization are available. The terminal hydroxyl group can be further modified by esterification, etherification, or other functional-group transformations. The aminooxy group can condense with aldehydes or ketones to form oxime bonds, providing a conjugation route for carbonyl-containing molecules and carriers. The two end groups can be coupled sequentially using compatible reactions and appropriate protection strategies, enabling surface immobilization, functional-molecule bridging, and directional spacer synthesis.

Customization available.