HO-PEG-OTs

Alpha-(hydroxy)-omega-(p-toluenesulfonate) poly(ethylene glycol) (HO-PEG-OTs) is a heterobifunctional precision PEG derivative with a defined chain length. The two ends bear hydroxyl and tosylate groups, respectively. Discrete chain lengths with different degrees of polymerization are available. The terminal hydroxyl group can be further modified by esterification, etherification, or other functional-group transformations. The tosylate acts as a leaving group, enabling nitrogen- or sulfur-containing functional moieties to be introduced by nucleophilic substitution. The two end groups can be coupled sequentially using compatible reactions and appropriate protection strategies, enabling surface immobilization, functional-molecule bridging, and directional spacer synthesis.

Customization available.