HO-PEG-Br

Alpha-(hydroxy)-omega-(bromo) poly(ethylene glycol) (HO-PEG-Br) is a heterobifunctional precision PEG derivative with a defined chain length. The two ends bear hydroxyl and bromo group groups, respectively. Discrete chain lengths with different degrees of polymerization are available. The terminal hydroxyl group can be further modified by esterification, etherification, or other functional-group transformations. The bromo terminus retains a handle for subsequent nucleophilic substitution, facilitating the introduction of nitrogen- or sulfur-containing linking moieties. The two end groups can be coupled sequentially using compatible reactions and appropriate protection strategies, enabling surface immobilization, functional-molecule bridging, and directional spacer synthesis.

Customization available.